FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Kpc21
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General Information
Symbol
Dmel\Kpc21
Species
D. melanogaster
Name
FlyBase ID
FBal0367430
Feature type
allele
Associated gene
Dmel\Kpc2
Associated Insertion(s)
TI{GAL4}Kpc21
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Li et al., 2020)
Mutagen
ends-out gene targeting
(Li et al., 2020)
Progenitor genotype
Associated Insertion(s)
TI{GAL4}Kpc21
Cytology
Description

Replacement of the N-terminal coding region of Kpc2 with GAL4 coding sequences and deleting ~1kb spanning the translation initiation codons of all Kpc2 isoforms.

(Li et al., 2020)
Allele components
Component
Use(s)
Inserted element
TI{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:19,670,755..19,671,884 [+]
Comment:

~1kb spanning the Kpc2 ATG and 5' coding sequences of all isoforms has been deleted and replaced with Scer\GAL4 coing sequences. Extent of deletion inferred from primer sequences.

(Li et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      After mating Kpc21 sperm does not reach the seminal receptacle.

      (Li et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Kpc21 is rescued by Kpc2βTub85D.B

      (Li et al., 2020)

      Kpc21 is rescued by Kpc2+t6.3

      (Li et al., 2020)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Kpc21
      dKpc21
      (Li et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)