FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\orion1
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General Information
Symbol
Dmel\orion1
Species
D. melanogaster
Name
FlyBase ID
FBal0367441
Feature type
allele
Associated gene
Dmel\orion
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Boulanger et al., 2021)
Mutagen
ethyl methanesulfonate
(Boulanger et al., 2021)
Progenitor genotype
Cytology
Description

Single nucleotide change inducing the substitution of the glycine (at position 629 for orion isoform A and 611 for orion isoform B) into an aspartic acid. The mutation lies in the common shared part of the isoforms and therefore affects both orion-A and -B functions.

(Boulanger et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:7,941,813..7,941,813 [-]
Nucleotide change:

G7941813A

Reported nucleotide change:

G?A

Amino acid change:

G629D | orion-PA; G611D | orion-PB

Reported amino acid change:

G629D

(Boulanger et al., 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      orion1 adults show a highly penetrant, cell non-autonomous mushroom body axon pruning phenotype, as revealed by the presence of adult unpruned vertical gamma axons as well as the strong presence of debris. The unpruned axon phenotype is particularly apparent during metamorphosis; no glial cell invasion of the gamma bundle is observed at 6h APF, and glial infiltration and engulfment of the degenerated larval axons is not observed at 12h APF nor at 24h APF. Dendrite pruning is also clearly affected.

      orion1/Df(1)BSC622 adults also show a mushroom body axon pruning phenotype.

      (Boulanger et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      orion1
      (Ji et al., 2023, Boulanger et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)