FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ythdf0
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General Information
Symbol
Dmel\Ythdf0
Species
D. melanogaster
Name
FlyBase ID
FBal0367714
Feature type
allele
Associated gene
Dmel\Ythdf
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Worpenberg et al., 2021)
Mutagen
CRISPR/Cas9
(Worpenberg et al., 2021)
Progenitor genotype
Cytology
Description

Deletion of 1,221 nucleotides in the coding sequence of Ythdf (deletes residues 172-557, including the YTH domain).

(Worpenberg et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:25,035,078..25,036,301 [-]
Comment:

Approximate breakpoints of the Ythdf0 deletion, which is reported to be a 1,221bp deletion that removes residues 172-557 of Ythdf. The deletion was mapped realtive to Ythdf-PA.

(Worpenberg et al., 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Ythdf0/Ythdf[+] is a non-suppressor of partially lethal - majority die phenotype of Nab2ex3

      (Lancaster et al., 2024)

      Ythdf0/Ythdf[+] is a non-suppressor of short lived phenotype of Nab2ex3

      (Lancaster et al., 2024)
      Other
      Statement
      Reference

      Nab2ex3, Ythdf0 has lethal phenotype

      (Lancaster et al., 2024)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ythdf#0
      (Worpenberg et al., 2021)
      Ythdf0
      (Lancaster et al., 2024)
      YthdfΔYTH
      (Lancaster et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)