FlyBase Allele Report: Dmel\ERp44[f20]

General Information

Symbol

Dmel\ERp44^f20

Species

D. melanogaster

Name

FlyBase ID

FBal0368741

Feature type

allele

Associated gene

Dmel\ERp44

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Bi et al., 2021)

Mutagen

CRISPR/Cas9

(Bi et al., 2021)

Progenitor genotype

Cytology

Description

Deletion of 5 bp of the coding sequence within the fourth exon of ERp44, causing a frame shift of the open reading frame.

(Bi et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:16,295,077..16,295,081 [-]

Comment:

The deletion of 5bp in the fourth coding exon of ERp44 causes a frameshift.

(Bi et al., 2021)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Bi et al., 2021)

decreased body weight | adult stage

(Bi et al., 2021)

fertile

(Bi et al., 2021)

short lived | calorie restriction conditional

(Bi et al., 2021)

viable

(Bi et al., 2021)

Phenotype Manifest In

embryonic/larval fat body | larval stage

(Bi et al., 2021)

lipid droplet | larval stage

(Bi et al., 2021)

Detailed Description

Statement

Reference

ERp44^f20 homozygotes show a developmental delay: 6h at the 3rd instar larval stage and 20h at the adult stage. The larval fat body exhibits larger lipid droplets. The adult fat body shows fewer and smaller lipid droplets.

(Bi et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

ERp44^f20 has lipid droplet | larval stage phenotype, enhanceable by Itpr^JF01957/Scer\GAL4^NP5440

(Bi et al., 2021)

ERp44^f20 has embryonic/larval fat body | larval stage phenotype, enhanceable by Itpr^JF01957/Scer\GAL4^NP5440

(Bi et al., 2021)

Suppressed by

Statement

Reference

ERp44^f20 has lipid droplet | larval stage phenotype, suppressible by RyR^HM05130/Scer\GAL4^NP5440

(Bi et al., 2021)

ERp44^f20 has embryonic/larval fat body | larval stage phenotype, suppressible by RyR^HM05130/Scer\GAL4^NP5440

(Bi et al., 2021)

ERp44^f20 has lipid droplet | larval stage phenotype, suppressible by Stim^HMC03651/Scer\GAL4^NP5440

(Bi et al., 2021)

ERp44^f20 has lipid droplet | larval stage phenotype, suppressible by Stim^UAS.cEa/Scer\GAL4^NP5440

(Bi et al., 2021)

ERp44^f20 has embryonic/larval fat body | larval stage phenotype, suppressible by Stim^HMC03651/Scer\GAL4^NP5440

(Bi et al., 2021)

ERp44^f20 has embryonic/larval fat body | larval stage phenotype, suppressible by Stim^UAS.cEa/Scer\GAL4^NP5440

(Bi et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG9911^f20

(Bi et al., 2021)

ERp44^f20

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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