FlyBase Allele Report: Dmel\L[gR1]

General Information

Symbol

Dmel\L^gR1

Species

D. melanogaster

Name

FlyBase ID

FBal0368842

Feature type

allele

Associated gene

Dmel\L

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Son and Choi, 2020)

Progenitor genotype

Cytology

Description

10bp deletion in the last exon of L. This results in a frameshift in the L-PB product after codon 268, removing most of the zinc-finger motifs.

(Son and Choi, 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:14,462,322..14,462,331 [+]

Comment:

An 10 bp-deletion (GCCGGTGGCA - position 805-814 bp of the L-RB CDS). The mutation leads to a frameshift and an early translation termination after the addition of 99 novel amino acids after A268 of L-PB.

(Choi, 2021.8.18)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2R)ED2354)

(Son and Choi, 2020)

lethal (with L^D0B)

(Son and Choi, 2020)

lethal (with L^rev6-3)

(Son and Choi, 2020)

majority die during embryonic stage | recessive

(Son and Choi, 2020)

viable (with L^A1c)

(Son and Choi, 2020)

viable (with L^A4c)

(Son and Choi, 2020)

Phenotype Manifest In

embryonic/larval posterior spiracle

(Son and Choi, 2020)

embryonic/larval posterior spiracle (with L^rev6-3)

(Son and Choi, 2020)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

L^D0B

(Son and Choi, 2020)

L^rev6-3

(Son and Choi, 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

L^gR1

(Son and Choi, 2020)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close