FlyBase Allele Report: Dmel\Uch[E8A]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Uch^E8A

General Information

Symbol

Dmel\Uch^E8A

Species

D. melanogaster

Name

FlyBase ID

FBal0369075

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

(Ham et al., 2021)

Progenitor genotype

Cytology

Description

Amino acid replacement: E8A.

(Ham et al., 2021)

An E8A knock-in mutation, equivalent to the E7A substitution in Hsap\UCHL1 that is associated with motor neuron dysfunctions similar to Parkinson's Disease.

(Ham et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

2L:2,213,909..2,213,909 [-]

Nucleotide change:

A2213909C

Reported nucleotide change:

A?C

Amino acid change:

E8A | Uch-PA; E8A | Uch-PB; E8A | Uch-PC

Reported amino acid change:

E8A

Comment:

An E8A knock-in mutation, equivalent to the E7A substitution in Hsap\UCHL1, which is associated with motor neuron dysfunctions similar to Parkinson's Disease.

(Ham et al., 2021)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Ham et al., 2021)

ameliorates Parkinson's disease 2

modeled by park¹

(Ham et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Ham et al., 2021)

UCHL1:p.Glu7Ala

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

Parkinson disease 5, susceptibility to

External database links

Comments concerning this variant

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Uch^E8A is a suppressor | partially of increased cell death | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Uch^E8A is a suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of decreased cell number | adult stage phenotype of park¹

(Ham et al., 2021)

Uch^E8A is a suppressor of abnormal locomotor behavior | adult stage phenotype of park¹

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of increased cell death | adult stage phenotype of park¹

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of decreased cell number | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

Uch^E8A is a suppressor | partially of dopaminergic PPM2 neuron | decreased number phenotype of park¹

(Ham et al., 2021)

Uch^E8A is a suppressor of dopaminergic PPL1 neuron | decreased number phenotype of park¹

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of mitochondrion | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of flight muscle cell | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of dopaminergic PPM1 neuron | decreased number phenotype of Pink1^B9

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of dopaminergic PPM2 neuron | decreased number phenotype of Pink1^B9

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of flight muscle cell | adult stage phenotype of park¹

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of mitochondrion | adult stage phenotype of park¹

(Ham et al., 2021)

Uch^E8A is a suppressor | partially of dopaminergic PPM1 neuron | decreased number phenotype of park¹

(Ham et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

UCH<up>E8A KI</up>

(Ham et al., 2021)

Uch^E8A

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections