FB2026_03 , released September 17, 2026
Allele: Dmel\UchH19Y
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General Information
Symbol
Dmel\UchH19Y
Species
D. melanogaster
Name
FlyBase ID
FBal0369076
Feature type
allele
Associated gene
Dmel\Uch
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Ham et al., 2021)
Progenitor genotype
Cytology
Description

Amino acid replacement: H19Y.

(Ham et al., 2021)

An H19Y knock-in mutation, equivalent to the S18Y substitution in Hsap\UCHL1 that several statistical studies have proposed reduces incidence of Parkinson's Disease

(Ham et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,213,738..2,213,738 [-]
Nucleotide change:

C2213738T

Reported nucleotide change:

C?T

Amino acid change:

H19Y | Uch-PA; H19Y | Uch-PB; H19Y | Uch-PC

Reported amino acid change:

H19Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Ham et al., 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      UchH19Y is a non-suppressor of decreased cell number | adult stage phenotype of Pink1B9

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of increased cell death | adult stage phenotype of Pink1B9

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of increased cell death | adult stage phenotype of park1

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of decreased cell number | adult stage phenotype of park1

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of park1

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1B9

      (Ham et al., 2021)
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      UchH19Y is a non-suppressor of flight muscle cell | adult stage phenotype of park1

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of dopaminergic PPL1 neuron | decreased number phenotype of park1

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of mitochondrion | adult stage phenotype of Pink1B9

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of flight muscle cell | adult stage phenotype of Pink1B9

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of dopaminergic PPM1 neuron | decreased number phenotype of Pink1B9

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of dopaminergic PPM2 neuron | decreased number phenotype of Pink1B9

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of mitochondrion | adult stage phenotype of park1

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of dopaminergic PPM1 neuron | decreased number phenotype of park1

      (Ham et al., 2021)

      UchH19Y is a non-suppressor of dopaminergic PPM2 neuron | decreased number phenotype of park1

      (Ham et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      UCH<up>H19Y KI</up>
      (Ham et al., 2021)
      UchH19Y
      Name Synonyms
      Secondary FlyBase IDs
        References (1)