FlyBase Allele Report: Dmel\CTCF[C1]

General Information

Symbol

Dmel\CTCF^C1

Species

D. melanogaster

Name

FlyBase ID

FBal0369965

Feature type

allele

Associated gene

Dmel\CTCF

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Kyrchanova et al., 2021)

Mutagen

CRISPR/Cas9

(Kyrchanova et al., 2021)

Progenitor genotype

Cytology

Description

1bp deletion that results in a premature stop codon in the CTCF coding sequence.

(Kyrchanova et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:7,356,404..7,356,404 [-]

Comment:

A 1bp deletion in codon 18 of CTCF that leads to a frameshift and early translation termination.

(Kyrchanova et al., 2021)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Kyrchanova et al., 2021)

female sterile (with CTCF^GE24185)

(Kyrchanova et al., 2021)

homeotic | adult stage

(Kyrchanova et al., 2021)

homeotic | adult stage (with CTCF^attP)

(Kyrchanova et al., 2021)

partially lethal - majority die

(Kyrchanova et al., 2021)

partially lethal - majority die (with CTCF^attP.mCh)

(Kyrchanova et al., 2021)

partially lethal - majority die (with CTCF^C2)

(Kyrchanova et al., 2021)

partially lethal - majority live (with CTCF^GE24185)

(Kyrchanova et al., 2021)

sterile

(Kyrchanova et al., 2021)

sterile (with CTCF^attP.mCh)

(Kyrchanova et al., 2021)

sterile (with CTCF^C2)

(Kyrchanova et al., 2021)

visible | adult stage

(Kyrchanova et al., 2021)

visible | adult stage (with CTCF^attP.mCh)

(Kyrchanova et al., 2021)

visible | adult stage (with CTCF^attP)

(Kyrchanova et al., 2021)

Phenotype Manifest In

abdominal sternite 6 | adult stage

(Kyrchanova et al., 2021)

abdominal sternite | adult stage

(Kyrchanova et al., 2021)

abdominal sternite | adult stage (with CTCF^attP)

(Kyrchanova et al., 2021)

adult external abdomen (with CTCF^attP.mCh)

(Kyrchanova et al., 2021)

adult external abdomen | adult stage

(Kyrchanova et al., 2021)

adult external abdomen | adult stage (with CTCF^attP)

(Kyrchanova et al., 2021)

genitalia | adult stage

(Kyrchanova et al., 2021)

genitalia | adult stage (with CTCF^attP.mCh)

(Kyrchanova et al., 2021)

genitalia | adult stage (with CTCF^C2)

(Kyrchanova et al., 2021)

genitalia | adult stage (with CTCF^GE24185)

(Kyrchanova et al., 2021)

wing

(Kyrchanova et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

CTCF^C1 is rescued by CTCF^Ubi-p63E.PK

(Kyrchanova et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CTCF^C1

(Kyrchanova et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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