FlyBase Allele Report: Dmel\bru1[M2]

General Information

Symbol

Dmel\bru1^M2

Species

D. melanogaster

Name

FlyBase ID

FBal0371659

Feature type

allele

Associated gene

Dmel\bru1

Associated Insertion(s)

TI{TI}bru1^M2

Carried in Construct

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Nikonova et al., 2022)

Mutagen

CRISPR/Cas9

(Nikonova et al., 2022)

Progenitor genotype

Associated Insertion(s)

TI{TI}bru1^M2

Cytology

Description

A cassette containing a splice acceptor followed by a triple frame stop and a Disc\RFP^{DsRed.3xP3.cUa} marker is inserted upstream of bru1 exon 12.

(Nikonova et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size

(Nikonova et al., 2022)

Phenotype Manifest In

indirect flight muscle cell

(Nikonova et al., 2022)

muscle cell

(Nikonova et al., 2022)

myofibril

(Nikonova et al., 2022)

sarcomere

(Nikonova et al., 2022)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

bru1^M2 is an enhancer of muscle cell phenotype of Rbfox1^JF02600, Scer\GAL4^Mef2.PR

(Nikonova et al., 2022)

bru1^M2 is an enhancer of myofibril phenotype of Rbfox1^JF02600, Scer\GAL4^Mef2.PR

(Nikonova et al., 2022)

bru1^M2 is an enhancer of sarcomere phenotype of Rbfox1^JF02600, Scer\GAL4^Mef2.PR

(Nikonova et al., 2022)

bru1^M2 is an enhancer of indirect flight muscle cell phenotype of Rbfox1^JF02600, Scer\GAL4^Mef2.PR

(Nikonova et al., 2022)

NOT Enhancer of

Statement

Reference

bru1^M2 is a non-enhancer of abdomen phenotype of Rbfox1^JF02600, Scer\GAL4^Mef2.PR

(Nikonova et al., 2022)

bru1^M2 is a non-enhancer of mesothoracic tergotrochanter muscle cell | adult stage phenotype of Rbfox1^JF02600, Scer\GAL4^Mef2.PR

(Nikonova et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

bru1^M2

(Nikonova et al., 2024, Nikonova et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (2)

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