FlyBase Allele Report: Dmel\αTub84B[K394R]

General Information

Symbol

Dmel\αTub84B^K394R

Species

D. melanogaster

Name

FlyBase ID

FBal0373252

Feature type

allele

Associated gene

Dmel\αTub84B

Associated Insertion(s)

TI{TI}αTub84B^K394R

Carried in Construct

Key Links

Allele class

Mutagen

phiC31 integrase

Nature of the Allele

Allele class

Mutagen

phiC31 integrase

(Saunders et al., 2022)

Progenitor genotype

αTub84B^KO-attP

(Saunders et al., 2022)

Associated Insertion(s)

TI{TI}αTub84B^K394R

Cytology

Description

αTub84B sequence which carries the K394R amino acid replacement has been knocked in to the attP site present in the αTub84B^KO-attP knockout line.

(Saunders et al., 2022)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Saunders et al., 2022)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage

(Saunders et al., 2022)

microtubule | larval stage

(Saunders et al., 2022)

NMJ bouton | ectopic | larval stage

(Saunders et al., 2022)

type Ib terminal bouton | increased number | larval stage

(Saunders et al., 2022)

type Is terminal bouton | decreased number | larval stage

(Saunders et al., 2022)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

αTub84B^K394R has microtubule | larval stage phenotype, non-enhanceable by Scer\GAL4^RapGAP1-OK6/HDAC6^H237A.UAS

(Saunders et al., 2022)

Suppressed by

Statement

Reference

αTub84B^K394R has type Ib terminal bouton | increased number | larval stage phenotype, suppressible by Scer\GAL4^RapGAP1-OK6/futsch^EP1419

(Saunders et al., 2022)

αTub84B^K394R has microtubule | larval stage phenotype, suppressible by Scer\GAL4^RapGAP1-OK6/futsch^EP1419

(Saunders et al., 2022)

αTub84B^K394R has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by Scer\GAL4^RapGAP1-OK6/futsch^EP1419

(Saunders et al., 2022)

αTub84B^K394R has type Ib terminal bouton | increased number | larval stage phenotype, suppressible by Tbce^UAS.cJa/Scer\GAL4^RapGAP1-OK6

(Saunders et al., 2022)

αTub84B^K394R has microtubule | larval stage phenotype, suppressible by Tbce^UAS.cJa/Scer\GAL4^RapGAP1-OK6

(Saunders et al., 2022)

αTub84B^K394R has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by Tbce^UAS.cJa/Scer\GAL4^RapGAP1-OK6

(Saunders et al., 2022)

αTub84B^K394R has type Is terminal bouton | larval stage | decreased number phenotype, suppressible by Scer\GAL4^RapGAP1-OK6/futsch^EP1419

(Saunders et al., 2022)

NOT suppressed by

Statement

Reference

αTub84B^K394R has microtubule | larval stage phenotype, non-suppressible by Scer\GAL4^RapGAP1-OK6/HDAC6^H237A.UAS

(Saunders et al., 2022)

NOT Enhancer of

Statement

Reference

αTub84B^K394R/αTub84B^K394R is a non-enhancer of microtubule | larval stage phenotype of HDAC6^H237A.UAS, Scer\GAL4^RapGAP1-OK6

(Saunders et al., 2022)

NOT Suppressor of

Statement

Reference

αTub84B^K394R/αTub84B^K394R is a non-suppressor of microtubule | larval stage phenotype of HDAC6^H237A.UAS, Scer\GAL4^RapGAP1-OK6

(Saunders et al., 2022)

Other

Statement

Reference

αTub84B^K394R, futsch^N94 has microtubule | larval stage phenotype

(Saunders et al., 2022)

αTub84B^K394R, futsch^N94 has embryonic/larval neuromuscular junction | larval stage phenotype

(Saunders et al., 2022)

αTub84B^K394R, futsch^N94 has type Ib terminal bouton | larval stage phenotype

(Saunders et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

αTub84B^K394R is rescued by Scer\GAL4^RapGAP1-OK6/αTub84B^UAS.cSa

(Saunders et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

αTub84B^K394R

(Saunders et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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