FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cnoΔRA
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General Information
Symbol
Dmel\cnoΔRA
Species
D. melanogaster
Name
FlyBase ID
FBal0373693
Feature type
allele
Associated gene
Dmel\cno
Associated Insertion(s)
TI{TI}cnoΔRA
Carried in Construct
Also Known As
cnoΔRA
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Perez-Vale et al., 2021)
Mutagen
CRISPR/Cas9
(Perez-Vale et al., 2021)
gene targeting by homologous recombination
(Perez-Vale et al., 2021)
Progenitor genotype
Associated Insertion(s)
TI{TI}cnoΔRA
Cytology
Description

Exons 2-6 of the endogenous cno locus have been deleted (the deletion starts in the first intron 605bp upstream of the translation start site in the second exon and ends 1398bp downstream of exon 6), and replaced by a sequence cassette that contains: 1. an attP site, 2. a loxP cassette containing a Disc\RFPDsRed(T1).3xP3.cHa marker. This allele produces wild-type levels of a truncated cno protein of approximately 200kD, probably due to aberrant splicing joining exon 1 to 7 and use of an alternative Met residue as a start codon (the first Met in exon 7 is at amino acid 340). The protein produced lacks Ras-association (RA) domain 1 and most of RA2 (as this sequence is removed by the deletion).

(Perez-Vale et al., 2021)
Allele components
Component
Use(s)
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cnoΔRA
      cnoΔRA
      (Peifer et al., 2023, Perez-Vale et al., 2023, Perez-Vale et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)