FlyBase Allele Report: Dmel\sif[MI02376-TG4.2]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\sif^{MI02376-TG4.2}

General Information

Symbol

Dmel\sif^{MI02376-TG4.2}

Species

D. melanogaster

Name

FlyBase ID

FBal0374526

Feature type

allele

Associated gene

Associated Insertion(s)

Mi{Trojan-GAL4.2}sif^{MI02376-TG4.2}

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

phiC31 integrase

Nature of the Allele

Allele class

loss of function allele

(Lu et al., 2022)

Mutagen

phiC31 integrase

(Lu et al., 2022)

Progenitor genotype

Mi{MIC}sif^MI02376

(Lu et al., 2022)

Associated Insertion(s)

Mi{Trojan-GAL4.2}sif^{MI02376-TG4.2}

Cytology

Description

The RMCE cassette in the Mi{MIC}sif^MI02376 insertion has been replaced with a cassette that contains a splice acceptor site followed by the T2A peptide, the GAL4 coding sequence and an polyA signal. This results in truncated sif and sif-driven GAL4.

(Lu et al., 2022)

Allele components

Component

Use(s)

Inserted element

Mi{Trojan-GAL4.2}

Encoded product / tool

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodevelopmental disorder with language delay and seizures

CEC

(Lu et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodevelopmental disorder with language delay and seizures

is ameliorated by Hsap\TIAM1^G328V.UAS

(Lu et al., 2022)

is ameliorated by Hsap\TIAM1^L862F.UAS

(Lu et al., 2022)

is ameliorated by Hsap\TIAM1^UAS.cBa

(Lu et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage (with Df(3L)BSC884)

(Lu et al., 2022)

bang sensitive (with Df(3L)BSC884)

(Lu et al., 2022)

paralytic | heat sensitive (with Df(3L)BSC884)

(Lu et al., 2022)

partially lethal - majority die

(Lu et al., 2022)

partially lethal - majority die (with Df(3L)BSC884)

(Lu et al., 2022)

short lived (with Df(3L)BSC884)

(Lu et al., 2022)

viable (with sif^ES11)

(Lu et al., 2022)

viable (with sif^MI07526)

(Lu et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

sif^{MI02376-TG4.2}/Df(3L)BSC884 adults show decreased climbing ability, bang sensitivity and heat-induced seizures.

(Lu et al., 2022)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Df(3L)BSC884/sif^{MI02376-TG4.2} has increased mortality during development phenotype, suppressible | partially by Hsap\TIAM1^UAS.cBa/Scer\GAL4^{sif-MI02376-TG4.2}

(Lu et al., 2022)

Df(3L)BSC884/sif^{MI02376-TG4.2} has short lived phenotype, suppressible | partially by Hsap\TIAM1^UAS.cBa/Scer\GAL4^{sif-MI02376-TG4.2}

(Lu et al., 2022)

Df(3L)BSC884/sif^{MI02376-TG4.2} has short lived phenotype, suppressible | partially by Scer\GAL4^{sif-MI02376-TG4.2}/Hsap\TIAM1^L862F.UAS

(Lu et al., 2022)

NOT suppressed by

Statement

Reference

Df(3L)BSC884/sif^{MI02376-TG4.2} has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Scer\GAL4^{sif-MI02376-TG4.2}/Hsap\TIAM1^L862F.UAS

(Lu et al., 2022)

Df(3L)BSC884/sif^{MI02376-TG4.2} has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Scer\GAL4^{sif-MI02376-TG4.2}/Hsap\TIAM1^R23C.UAS

(Lu et al., 2022)

Df(3L)BSC884/sif^{MI02376-TG4.2} has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Hsap\TIAM1^UAS.cBa/Scer\GAL4^{sif-MI02376-TG4.2}

(Lu et al., 2022)

Df(3L)BSC884/sif^{MI02376-TG4.2} has paralytic | heat sensitive phenotype, non-suppressible by Hsap\TIAM1^UAS.cBa/Scer\GAL4^{sif-MI02376-TG4.2}

(Lu et al., 2022)

Df(3L)BSC884/sif^{MI02376-TG4.2} has short lived phenotype, non-suppressible by Scer\GAL4^{sif-MI02376-TG4.2}/Hsap\TIAM1^R23C.UAS

(Lu et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Df(3L)BSC884/sif^{MI02376-TG4.2} is partially rescued by sif^UAS.cSa/Scer\GAL4^{sif-MI02376-TG4.2}

(Lu et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sif^{MI02376-TG4.2}

sif^T2A-GAL4

(Lu et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections