FlyBase Allele Report: Dmel\flw[XE55E]

General Information

Symbol

Dmel\flw^XE55E

Species

D. melanogaster

Name

FlyBase ID

FBal0384548

Feature type

allele

Associated gene

Dmel\flw

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Yamamoto et al., 2013, Yamamoto et al., 2013-)

Progenitor genotype

Cytology

Description

Amino acid replacement: K156term.

(Haelterman et al., 2014, Yamamoto et al., 2013-)

Nonsense mutation: K25Stop in the short isoform, K156Stop in the long isoform.

(Yamamoto et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:10,406,373..10,406,373 [+]

Nucleotide change:

A10406373T

Amino acid change:

K156term | flw-PA; K25term | flw-PB; K25term | flw-PC; K25term | flw-PD

Reported amino acid change:

K156term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The amino acid change was reported as K25Stop in the short isoform and K156Stop in the long isoform.

(Yamamoto et al., 2013)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Yamamoto et al., 2013)

lethal - all die before end of larval stage

(Yamamoto et al., 2013)

Phenotype Manifest In

egg | germline clone | maternal effect

(Yamamoto et al., 2013)

nurse cell ring canal | germline clone

(Yamamoto et al., 2013)

Detailed Description

Statement

Reference

Females containing homozygous germline clones produce small, non-fertile eggs. The homozygous germline clones have small actin ring canals during oogenesis. The normal set of four mitotic divisions occurs in the homozygous germline clones, and fusome formation and distribution are also unaffected. Homozygous clones in the somatic follicle cells do not results in a small actin ring canal phenotype.

(Yamamoto et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions