FB2026_02 , released June 18, 2026
Allele: Dmel\cic8
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General Information
Symbol
Dmel\cic8
Species
D. melanogaster
Name
FlyBase ID
FBal0386161
Feature type
allele
Associated gene
Dmel\cic
Associated Insertion(s)
TI{TI}cic8
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Rodríguez-Muñoz et al., 2022)
Mutagen
CRISPR/Cas9
(Rodríguez-Muñoz et al., 2022)
gene targeting by homologous recombination
(Rodríguez-Muñoz et al., 2022)
cre recombinase
(Rodríguez-Muñoz et al., 2022)
Progenitor genotype
Associated Insertion(s)
TI{TI}cic8
Cytology
Description

Three copies of the Tag:HA tag and a loxP site replace N-terminal coding sequence of the cic-L isoform.

(Jimenez, 2023.2.15)

Three copies of the Tag:HA tag replace coding sequence spanning from codons 117 to 751 of endogenous cic. Removes most of the cic-L N-terminal ('L'/long corresponds to isoform D).

(Rodríguez-Muñoz et al., 2022)
Allele components
Component
Use(s)
Tagged with
Tag:HA
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:20,288,429..20,291,068 [+]
Inserted_sequence:

GTGATCGAGGCCTACCCATACGATGTTCCTGACTATGCGGGCTATCCCTATGACGTCCCGGACTATGCAGGATCCTATCCATATGACGTTCCAGATTACGCGGCTCGCGATAGATCTCAGATAACTTCGTATAATGTATGCTATACGAAGTTATATAGATCTCAGCGGCCGCGGTACC

Comment:

Three copies of the Tag:HA tag and a loxP site replace cic-RD and cic-RG

N-terminal coding sequences.

(Jimenez, 2023.2.15)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      cic8 is rescued by cicL.NTer.Tag:HA

      (Rodríguez-Muñoz et al., 2022)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cic8
      (Rodríguez-Muñoz et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)