FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rtnl118
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General Information
Symbol
Dmel\Rtnl118
Species
D. melanogaster
Name
FlyBase ID
FBal0389730
Feature type
allele
Associated gene
Dmel\Rtnl1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Pérez-Moreno et al., 2023)
Progenitor genotype
Cytology
Description

Contains two deletions (6bp and 19bp) within the Rtnl1 coding sequence, plus an inversion of the sequence between the two deletions. This inverts the sequence encoding the first intramembrane domain and deletes some of the sequence encoding the second intramembrane domain, leaving only the C-terminal half of the domain potentially able to be translated from an in-frame AUG codon.

(Pérez-Moreno et al., 2023)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:4,994,548..4,994,984 [-]
Inserted_sequence:

ATGACGCCGAACTTGATCGAATCGATGATATCCTCAACAAGAAACAGACGCCTCAGCTCGGAGATGAAGCCATTGATATGTGCCACAGCCACGCCGGCAATGTTCTGTACCTTTTCGTGCGACAGCGTCAGATCCAGCTCCAGGTAATCCCTGATTTCGTAAGGAGTTACGTTAGTTAAACTTTTTTTTTTGTTGGGAGACATCAGTCTACAATACTCACTTAAAGGGGTGACCCTCGTTTGTCTTTTGCACGGCCTGTGTCACAGATTTGTAGATTCTGAAGGCGACGGTGCCGAAGAGGGTTAGGAGCGACAAGTAGGCGAACACGCTGATCACCGAGAAGCTGGAGATGGCCGCCAGTGTGATCAGGCCAGCGCCGAAGACAATGCCGGATTTCTTCACATCGCGCCA

Comment:

Contains two deletions (6bp and 19bp) within the Rtnl1 coding sequence flanking an inversion of the sequence between the two deletions.

(Pérez-Moreno et al., 2023)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hereditary spastic paraplegia 12
      CEA
      (Pérez-Moreno et al., 2023)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  hereditary spastic paraplegia 12
      is ameliorated by StimUAS.mCherry
      (Pérez-Moreno et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rtnl118
      (Pérez-Moreno et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)