FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Rtnl1
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General Information
Symbol
Dmel\Rtnl1
Species
D. melanogaster
Name
Reticulon-like1
Annotation Symbol
CG33113
Feature Type
protein_coding_gene
FlyBase ID
FBgn0053113
Gene Model Status
Current
Stock Availability
28 publicly available
Gene Summary
Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. [Date last reviewed: 2018-11-15] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Reticulon

Key Links
Genomic Location
Cytogenetic map
25B9-25C1
Sequence location
Recombination map
2-14
RefSeq locus
NT_033779 REGION:4992808..5009720
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables endoplasmic reticulum-autophagosome adaptor activity
inferred from direct assay
(Wang et al., 2023)
enables phospholipid binding
inferred from direct assay
(Espadas et al., 2019)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum organization
inferred from mutant phenotype
(Yalçın et al., 2017, O'Sullivan et al., 2012)
involved_in endoplasmic reticulum tubular network membrane organization
inferred from mutant phenotype
(Espadas et al., 2019, Fowler and O'Sullivan, 2016)
involved_in endoplasmic reticulum tubular network organization
inferred from mutant phenotype
(Pérez-Moreno et al., 2023)
involved_in membrane bending
inferred from mutant phenotype
(Espadas et al., 2019)
involved_in reticulophagy
inferred from mutant phenotype
(Wang et al., 2023)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum tubular network membrane organization
inferred from biological aspect of ancestor with PANTHER:PTN000107445
(GO Reference Genome Project, 2011-)
involved_in membrane bending
traceable author statement
(Pérez-Moreno et al., 2023)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
located_in axonal growth cone
inferred from direct assay
(Rao et al., 2016)
located_in axon
inferred from direct assay
(Yalçın et al., 2017, O'Sullivan et al., 2012)
located_in cytoplasm
inferred from direct assay
(Pokrywka et al., 2009, Wakefield and Tear, 2006)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
is_active_in endoplasmic reticulum membrane
inferred from direct assay
(Wang et al., 2023, Espadas et al., 2019)
located_in endoplasmic reticulum
inferred from direct assay
(Wakefield and Tear, 2006)
inferred from high throughput direct assay
(Lye et al., 2014)
located_in fusome
inferred from direct assay
(Lighthouse et al., 2008, Roper, 2007)
located_in smooth endoplasmic reticulum
inferred from direct assay
(Rao et al., 2016, O'Sullivan et al., 2012, Roper, 2007)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in axon
inferred from biological aspect of ancestor with PANTHER:PTN000107559
(GO Reference Genome Project, 2011-)
is_active_in endoplasmic reticulum membrane
inferred from biological aspect of ancestor with PANTHER:PTN000107445
(GO Reference Genome Project, 2011-)
is_active_in endoplasmic reticulum tubular network membrane
inferred by curator from GO:0071786
(Pérez-Moreno et al., 2023)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. [Date last reviewed: 2018-11-15]
Summary (Interactive Fly)

a reticulon family member, with intramembrane hairpin domains that insert into the cytosolic face of the endoplasmic reticulum (ER) thereby curving it and promoting ER tubule formation - enriched on tubular ER, including axons and egg chamber fusomes - high level leads to ER fragmentation - microtubule cytoskeleton is involved in Rtnl1 localization to spindles during mitosis

Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
7

Please see the JBrowse view of Dmel\Rtnl1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry E1JHT6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rtnl1-RA
FBtr0079042
NM_175973
1428
222
Rtnl1-RB
FBtr0079039
NM_175970
1539
234
Rtnl1-RC
FBtr0079043
NM_175974
1267
202
Rtnl1-RD
FBtr0079041
NM_175972
1000
224
Rtnl1-RE
FBtr0079040
NM_175971
1511
234
Rtnl1-RF
FBtr0079038
NM_175969
2700
595
Rtnl1-RG
FBtr0079044
NM_205908
2271
224
Rtnl1-RH
FBtr0301538
NM_001169404
2231
607
Rtnl1-RI
FBtr0301539
NM_001169405
1495
234
Rtnl1-RJ
FBtr0301540
NM_001169406
2311
234
Rtnl1-RL
FBtr0332413
NM_001169407
1475
222
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Rtnl1-PA
FBpp0078678
24.7
222
9.68
Q9VMW4
NP_787987
AAF52195
Rtnl1-PB
FBpp0078675
26.2
234
8.65
Q7KTP4
NP_787984
AAF52197
Rtnl1-PC
FBpp0078679
22.6
202
9.26
Q9VMW2
NP_787988
AAF52196
Rtnl1-PD
FBpp0078677
24.9
224
6.97
Q9VMW1
NP_787986
AAF52198
Rtnl1-PE
FBpp0078676
26.2
234
8.65
Q7KTP4
NP_787985
AAF52194
Rtnl1-PF
FBpp0078674
63.9
595
4.43
Q9VMV9
NP_787983
AAF52199
Rtnl1-PG
FBpp0078680
24.9
224
6.97
Q9VMW1
NP_995630
AAS64638
Rtnl1-PH
FBpp0290753
65.4
607
4.47
E1JHT6
NP_001162875
ACZ94166
Rtnl1-PI
FBpp0290754
26.2
234
8.65
Q7KTP4
NP_001162876
ACZ94167
Rtnl1-PJ
FBpp0290755
26.2
234
8.65
Q7KTP4
NP_001162877
ACZ94168
Rtnl1-PL
FBpp0304686
24.7
222
8.20
E1JHT9
NP_001162878
ACZ94169
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

234 aa isoforms: Rtnl1-PB, Rtnl1-PE, Rtnl1-PI, Rtnl1-PJ
224 aa isoforms: Rtnl1-PD, Rtnl1-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rtnl1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.88

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 13 -- 16
amnioserosa
(Fisher et al., 2012)
embryonic dorsal apodeme
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic ventral apodeme
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
wandering third instar larval stage
wing pouch | restricted
(Molnar et al., 2012)
wing hinge primordium | restricted
(Molnar et al., 2012)
pcr
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
organism
(O'Sullivan et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axonal growth cone
inferred from direct assay
(Rao et al., 2016)
located_in axon
inferred from direct assay
(Yalçın et al., 2017, O'Sullivan et al., 2012)
located_in cytoplasm
inferred from direct assay
(Pokrywka et al., 2009, Wakefield and Tear, 2006)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
is_active_in endoplasmic reticulum membrane
inferred from direct assay
(Wang et al., 2023, Espadas et al., 2019)
located_in endoplasmic reticulum
inferred from direct assay
(Wakefield and Tear, 2006)
inferred from high throughput direct assay
(Lye et al., 2014)
located_in fusome
inferred from direct assay
(Lighthouse et al., 2008, Roper, 2007)
located_in smooth endoplasmic reticulum
inferred from direct assay
(Rao et al., 2016, O'Sullivan et al., 2012, Roper, 2007)
Expression Deduced from Reporters
Reporter: P{PTT-GA}Rtnl1CA06523
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
germarium
• fusome
(Lighthouse et al., 2008)
adult stage | male
male germline cyst
(Lighthouse et al., 2008)
Reporter: P{PTT-un}Rtnl1G00071
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval central nervous system
(Roper, 2007)
embryonic/larval hypodermal muscle cell
(Roper, 2007)
embryonic stage 4
epidermis | ubiquitous
(Roper, 2007)
amnioserosa
(Roper, 2007)
oogenesis & adult stage | female
nurse cell
(Roper, 2007)
oocyte
(Roper, 2007)
female germline cyst
• fusome
(Roper, 2007)
oogenesis
germline cell
(Etchegaray et al., 2012)
Reporter: PBac{681.P.FSVS-1}Rtnl1CPTI001291
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval ventral nerve cord | intense
(O'Sullivan et al., 2012)
embryonic/larval epidermis
(O'Sullivan et al., 2012)
larval peripheral nervous system | restricted
(O'Sullivan et al., 2012)
embryonic/larval neuromuscular junction
(O'Sullivan et al., 2012)
motor neuron | restricted
(O'Sullivan et al., 2012)
adult stage
adult brain | faint | ubiquitous
(Knowles-Barley, 2011.8.24)
adult optic lobe
(Knowles-Barley, 2011.8.24)
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
Reporter: PBac{769.FSVS-1}Rtnl1CPTI002200
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult mushroom body
(Knowles-Barley, 2011.8.24)
adult brain
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rtnl1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 44 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rtnl1
Transgenic constructs containing regulatory region of Rtnl1
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4da.G32
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal behavior | recessive
abnormal learning | adult stage
abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4da.G32
abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4nSyb.PS
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4elav-C155
abnormal neurophysiology | larval stage
abnormal neurophysiology | larval stage (with Rtnl11.W)
abnormal neurophysiology | larval stage (with Rtnl118)
abnormal neurophysiology | third instar larval stage
abnormal neurophysiology | third instar larval stage, with Scer\GAL4elav-C155
abnormal neurophysiology | third instar larval stage, with Scer\GAL4Gli.PU
abnormal neurophysiology | third instar larval stage, with Scer\GAL4Mef2.PR
abnormal neurophysiology | third instar larval stage, with Scer\GAL4Toll-6-D42
abnormal smell perception
short lived
short lived, with Scer\GAL4da.G32
short lived | heat sensitive
Phenotype manifest in
Allele
axon | third instar larval stage
axon | third instar larval stage, with Scer\GAL4RapGAP1-OK6
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Pxn.PS
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav-C155
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Gli.PU
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Mef2.PR
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Toll-6-D42
endoplasmic reticulum, with Scer\GAL4RapGAP1-OK6
endoplasmic reticulum | decreased number | larval stage
endoplasmic reticulum | decreased number | larval stage, with Scer\GAL4Toll-6-D42
endoplasmic reticulum | decreased number | larval stage (with Rtnl11.W)
endoplasmic reticulum | decreased number | larval stage (with Rtnl118)
endoplasmic reticulum | third instar larval stage
mitochondrion, with Scer\GAL4RapGAP1-OK6
mitochondrion | third instar larval stage, with Scer\GAL4RapGAP1-OK6
motor neuron | third instar larval stage, with Scer\GAL4RapGAP1-OK6
NMJ bouton | third instar larval stage, with Scer\GAL4elav-C155
type I bouton | increased number | larval stage
type I bouton | larval stage
type I bouton | larval stage, with Scer\GAL4Toll-6-D42
type I bouton | larval stage (with Rtnl11.W)
type I bouton | larval stage (with Rtnl118)
wing blade posterior compartment, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\RTN4
10 of 14
Yes
Yes
1  
Hsap\RTN1
8 of 14
No
Yes
1  
Hsap\RTN3
7 of 14
No
Yes
1  
Hsap\RTN2
5 of 14
No
Yes
Hsap\PRR18
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Rtn1
8 of 14
Yes
Yes
Rnor\Rtn4
8 of 14
Yes
Yes
Rnor\Rtn3
7 of 14
No
Yes
Rnor\Rtn2
5 of 14
No
Yes
Rnor\Prr18
1 of 14
No
Yes
Mus musculus (laboratory mouse) (6)
Mmus\Rtn1
9 of 14
Yes
Yes
Mmus\Rtn4
9 of 14
Yes
Yes
Mmus\Rtn3
7 of 14
No
Yes
Mmus\Rtn2
5 of 14
No
Yes
Mmus\Prr18
1 of 14
No
Yes
Mmus\Zan
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\rtn1
6 of 13
Yes
Yes
Xtro\rtn3
4 of 13
No
No
Xtro\maml1
3 of 13
No
No
Xtro\ptchd4
3 of 13
No
No
Xtro\rtn2
3 of 13
No
Yes
Xtro\rtn4
3 of 13
No
No
Xtro\cndp2
1 of 13
No
No
Xtro\htr6
1 of 13
No
Yes
Xtro\slc11a2
1 of 13
No
No
Xtro\slc26a4l
1 of 13
No
No
Danio rerio (Zebrafish) (8)
Drer\rtn1a
10 of 14
Yes
Yes
Drer\rtn1b
10 of 14
Yes
Yes
Drer\rtn4a
8 of 14
No
Yes
Drer\rtn2a
4 of 14
No
No
Drer\rtn2b
4 of 14
No
Yes
Drer\rtn3
3 of 14
No
No
Drer\rtn4b
2 of 14
No
No
Drer\prr18
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ret-1
7 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP007940
6 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (21)
Atha\AT2G46170
4 of 13
Yes
No
Atha\BTI3
4 of 13
Yes
No
Atha\AT1G68230
3 of 13
No
No
Atha\AT2G01240
3 of 13
No
No
Atha\AT2G15280
3 of 13
No
No
Atha\AT3G10260
3 of 13
No
No
Atha\AT3G10915
3 of 13
No
No
Atha\AT3G18260
3 of 13
No
No
Atha\AT3G19460
3 of 13
No
No
Atha\AT3G54120
3 of 13
No
No
Atha\AT3G61560
3 of 13
No
No
Atha\AT4G01230
3 of 13
No
No
Atha\BTI1
3 of 13
No
No
Atha\BTI2
3 of 13
No
No
Atha\RTNLB3
3 of 13
No
No
Atha\RTNLB13
3 of 13
No
No
Atha\3BETAHSD/D2
1 of 13
No
No
Atha\AT2G20590
1 of 13
No
Yes
Atha\AT2G43420
1 of 13
No
No
Atha\AT4G28430
1 of 13
No
No
Atha\AT5G58000
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\RTN1
5 of 13
Yes
Yes
Scer\RTN2
5 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rtn1
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rtnl1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
Rtnl2
6 of 13
CG42853
3 of 13
dpy
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
RTN2; reticulon 2
model of  hereditary spastic paraplegia 12
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RTN4; reticulon 4
10 of 14
604475
       
      RTN1; reticulon 1
      8 of 14
      600865
           
          RTN3; reticulon 3
          7 of 14
          604249
               
              RTN2; reticulon 2
              5 of 14
              603183
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Rtnl1
              suppressible
              atl
              (Summerville et al., 2016)
              Rtnl1
              suppressible
              Drp1
              (Fowler and O'Sullivan, 2016)
              Rtnl1
              enhanceable
              ReepA|ReepB
              (Yalçın et al., 2017)
              Rtnl1
              enhanceable
              ReepB
              (Yalçın et al., 2017)
              Rtnl1
              suppressible
              Stim
              (Pérez-Moreno et al., 2023)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              atl
              suppressible
              Rtnl1
              (Summerville et al., 2016)
              External Data
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2L
              Recombination map
              2-14
              Cytogenetic map
              25B9-25C1
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              25B9-25C1
              Limits computationally determined from genome sequence between P{lacW}l(2)k10001k10001 and P{lacW}vkgk16721&P{lacW}Cg25Ck00405
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              Experimentally Determined Recombination Data
              Location

              2-14

              (FlyBase, 2016)

              2-16.3

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (28)
              Genomic Clones (14)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (477)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: CG18623 CG8895

                  (FlyBase Genome Annotators, 2002-2003)
                  Additional comments

                  Annotations CG18623 and CG8895 merged as CG33113 in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)

                  Source for identity of Rtnl1 CG33113 was sequence comparison ( date:030717 ).

                  (FlyBase, 1996-)
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: Rtnl1 CG33113

                  (FlyBase, 1996-)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (17)
                  Reported As
                  Symbol Synonym
                  142893_at
                  (Kristensen et al., 2005)
                  CG18623
                  (Mount, 2001.8.14)
                  CG33113
                  (National Institute of Genetics Fly Stocks, 2022-, Anderson-Baron and Simmonds, 2018, Çiçek et al., 2016, Krahmer et al., 2013, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Keleman et al., 2009.8.5, Rach et al., 2009, Quinones-Coello, 2007, Beller et al., 2006, Molnar et al., 2006, Giot et al., 2003)
                  CG8895
                  (Raisin et al., 2003, Morin et al., 2001)
                  G9
                  (Kaushik et al., 2002)
                  RTNL1
                  (Guan et al., 2020)
                  Retl1
                  (Zhang et al., 2014)
                  Rtn1
                  (Ryoo, 2015)
                  Rtnl-1
                  (Pokrywka et al., 2009)
                  Rtnl1
                  (Rommelaere et al., 2025, Sung, 2025, Mou et al., 2024, Sung and Lloyd, 2024, Praschberger et al., 2023, Zheng et al., 2023, Cassella and Ephrussi, 2022, Deolankar et al., 2022, Jia et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Palozzi et al., 2022, Anqueira-González et al., 2021, Oliva et al., 2020, Warecki et al., 2020, Espadas et al., 2019, Anderson-Baron and Simmonds, 2018, Betancourt-Solis et al., 2018, Gene Disruption Project members, 2018-, Levis, 2018.8.30, Casas-Vila et al., 2017, Hu et al., 2017.6.13, Mohr et al., 2017, Sharma et al., 2017, Fowler and O'Sullivan, 2016, Jegla et al., 2016, Rao et al., 2016, Summerville et al., 2016, Xu et al., 2016, de Celis et al., 2013.9.11, Kwon et al., 2013, Lavagnino et al., 2013, Eddison et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kitazawa et al., 2012, Malone et al., 2012, Murray et al., 2012, O'Sullivan et al., 2012, Rees et al., 2011, Gan et al., 2010, Wasbrough et al., 2010, Edwards et al., 2009, Orso et al., 2009, Pokrywka et al., 2009, Rach et al., 2009, Tan et al., 2009, FlyBase Curators, 2008-, Harbison and Sehgal, 2008, Lighthouse et al., 2008, Pokrywka et al., 2008, Stofanko et al., 2008, Xun et al., 2008, Buszczak et al., 2007, Lighthouse et al., 2007, Quinones-Coello, 2007, Quinones-Coello et al., 2007, Roper, 2007, Beller et al., 2006, Beller et al., 2006, Kristensen et al., 2006, Molnar et al., 2006, Sambandan et al., 2006, Wakefield and Tear, 2006)
                  rtnl1
                  (Roper, 2007, Oertle et al., 2003)
                  Name Synonyms
                  Reticulon
                  (Zhang et al., 2014, Krahmer et al., 2013)
                  Reticulon-like 1
                  (Anderson-Baron and Simmonds, 2018, Rees et al., 2011)
                  Reticulon-like1
                  (Pokrywka et al., 2009)
                  Rtnl1
                  (Jaspers et al., 2012, Cammarato et al., 2011)
                  reticulon
                  (Pokrywka et al., 2009)
                  reticulon-like 1
                  (Roper, 2007, Wakefield and Tear, 2006)
                  reticulon-like1
                  (Texada et al., 2011)
                  Secondary FlyBase IDs
                  • FBgn0031666
                  • FBgn0031667
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 116 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (136)