FlyBase Gene Report: Dmel\ReepA

General Information

Symbol

Dmel\ReepA

Species

D. melanogaster

Name

Receptor expression enhancing protein A

Annotation Symbol

CG42678

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261564

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Summary

Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

Reep1, REEP1 homolog

Key Links

Genomic Location

Cytogenetic map

59B6-59B6

Sequence location

2R:22,925,107..22,932,044 [+]

Recombination map

2-101

RefSeq locus

NT_033778 REGION:22925107..22932044

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables microtubule binding

inferred from biological aspect of ancestor with PANTHER:PTN000959166

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in endoplasmic reticulum organization

inferred from mutant phenotype

(Yalçın et al., 2017)

involved_in response to endoplasmic reticulum stress

inferred from mutant phenotype

(Appocher et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in endoplasmic reticulum tubular network organization

inferred from biological aspect of ancestor with PANTHER:PTN000959055

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in endoplasmic reticulum

inferred from direct assay

(Yalçın et al., 2017, Appocher et al., 2014)

located_in presynapse

inferred from direct assay

(Yalçın et al., 2017)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cytoplasmic microtubule

inferred from biological aspect of ancestor with PANTHER:PTN000959166

(GO Reference Genome Project, 2011-)

is_active_in endoplasmic reticulum membrane

inferred from biological aspect of ancestor with PANTHER:PTN000959166

(GO Reference Genome Project, 2011-)

is_active_in endoplasmic reticulum tubular network

inferred from biological aspect of ancestor with PANTHER:PTN000959055

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

TB2/DP1/HVA22

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ReepA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4JCU3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Gene model includes transcripts encoding non-overlapping portions of the full CDS.

Alternative translation stop created by use of multiphasic reading frames within coding region.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ReepA-RD

FBtr0302766

NM_166576

1573

435

ReepA-RE

FBtr0302767

NM_166574

1469

288

ReepA-RG

FBtr0302768

NM_001103955

2534

288

ReepA-RH

FBtr0302769

NM_001202058

2715

569

ReepA-RI

FBtr0302770

NM_001202059

2755

716

ReepA-RJ

FBtr0302771

NM_001202060

2718

570

ReepA-RK

FBtr0302772

NM_137893

1931

408

ReepA-RL

FBtr0302773

NM_001103956

1243

151

ReepA-RO

FBtr0336697

NM_001274215

1321

291

ReepA-RP

FBtr0344190

NM_001202061

2601

538

ReepA-RQ

FBtr0345077

NM_001299820

2641

685

ReepA-RR

FBtr0345078

NM_001299821

1863

459

ReepA-RS

FBtr0345079

NM_001299822

1823

312

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

ReepA-PD

FBpp0291906

49.5

435

8.40

FBpp0291907

32.8

288

9.08

FBpp0291908

32.8

288

9.08

FBpp0291909

63.9

569

5.26

FBpp0291910

80.7

716

5.40

FBpp0291911

64.0

570

5.26

FBpp0291912

45.3

408

4.79

FBpp0291913

16.3

151

10.91

FBpp0307678

33.7

291

8.93

FBpp0310602

60.4

538

5.23

FBpp0311307

77.2

685

5.38

FBpp0311308

51.7

459

9.48

FBpp0311309

34.9

312

10.05

A0A0B4LG73

NP_001286751

AHN56546

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

288 aa isoforms: ReepA-PE, ReepA-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

TB2/DP1/HVA22

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ReepA using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.52

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

• cytoplasm | basal

Comment: apically cleared

(Fisher et al., 2012)

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

midline primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

Comment: isoform expression analyzed

(Appocher et al., 2014)

adult thorax

Comment: assayed together with abdomen, isoform expression analyzed

(Appocher et al., 2014)

adult abdomen

Comment: assayed together with abdomen, isoform expression analyzed

(Appocher et al., 2014)

Additional Descriptive Data

The expression of multiple ReepA isoforms was analyzed in adult heads and bodies.

(Appocher et al., 2014)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval hypodermal muscle cell

(Appocher et al., 2014)

motor neuron

(Appocher et al., 2014)

larval brain

(Appocher et al., 2014)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

ReepA expression is observed in endoplasmic reticulum in larval motor neurons and muscle cells.

(Appocher et al., 2014)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endoplasmic reticulum

inferred from direct assay

(Yalçın et al., 2017, Appocher et al., 2014)

located_in presynapse

inferred from direct assay

(Yalçın et al., 2017)

Expression Deduced from Reporters

Reporter: PBac{681.P.FSVS-1}ReepA^CPTI001117

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ReepA in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ReepA

View exonic expression by tissue for Dmel\ReepA

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261564

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37643/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261564

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261564

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ReepA

Transgenic constructs containing regulatory region of ReepA

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel7176

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

ReepA^GD2168

viable, with Scer\GAL4^pnr-MD237

ReepA^GD10021

viable, with Scer\GAL4^tin.CΔ4

ReepA^GD2168

viable (with Df(2R)BSC784)

Sterility

Allele

fertile

fertile (with Df(2R)BSC784)

Other Phenotypes

Allele

abnormal heat stress response

abnormal heat stress response (with Df(2R)BSC784)

abnormal heat stress response (with ReepA^Δ258)

ReepA^Δ275

abnormal heat stress response (with ReepA^Δ275)

ReepA^Δ258

abnormal locomotor behavior | adult stage

ReepA⁵⁴¹

abnormal stress response

abnormal stress response (with Df(2R)BSC784)

abnormal stress response (with ReepA^Δ258)

ReepA^Δ275

abnormal stress response (with ReepA^Δ275)

ReepA^Δ258

short lived

ReepA⁵⁴¹

Phenotype manifest in

Allele

A1-7 ventral longitudinal muscle cell | larval stage

ReepA⁵⁴¹

A1-7 ventral longitudinal muscle cell | larval stage, with Scer\GAL4^αTub84B.PL

ReepA^{UAS.E.Tag:MYC}

endoplasmic reticulum lumen | decreased number | larval stage, with Scer\GAL4^αTub84B.PL

ReepA^{UAS.E.Tag:MYC}

endoplasmic reticulum lumen | increased number | larval stage

ReepA⁵⁴¹

endoplasmic reticulum lumen | larval stage

ReepA⁵⁴¹

endoplasmic reticulum lumen | larval stage, with Scer\GAL4^αTub84B.PL

ReepA^{UAS.E.Tag:MYC}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (6)

Hsap\REEP2

9 of 14

Yes

Hsap\REEP4

9 of 14

Yes

Hsap\REEP1

7 of 14

Yes

Hsap\REEP3

6 of 14

Yes

Hsap\REEP5

3 of 14

Hsap\REEP6

3 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Reep4

9 of 14

Yes

Rnor\Reep1

7 of 14

Yes

Rnor\Reep2

7 of 14

Yes

Rnor\Reep3

6 of 14

Yes

Rnor\Reep5

3 of 14

Rnor\Reep6

3 of 14

Mus musculus (laboratory mouse) (6)

Mmus\Reep2

9 of 14

Yes

Mmus\Reep4

9 of 14

Yes

Mmus\Reep1

6 of 14

Yes

Mmus\Reep3

6 of 14

Yes

Mmus\Reep5

3 of 14

Mmus\Reep6

2 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\reep2

7 of 13

Yes

Xtro\reep4

6 of 13

Yes

Xtro\reep1

5 of 13

Xtro\reep3

4 of 13

Yes

Xtro\malt1

1 of 13

Xtro\reep5

1 of 13

Xtro\reep6

1 of 13

Danio rerio (Zebrafish) (7)

Drer\reep2

9 of 14

Yes

Drer\reep1

7 of 14

Yes

Drer\reep3a

6 of 14

Yes

Drer\reep3b

6 of 14

Yes

Drer\zgc:101744

3 of 14

Drer\reep5

2 of 14

Drer\reep6

2 of 14

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\T19C3.4

10 of 14

Yes

Cele\C06E1.1

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP011331

7 of 12

Yes

Agam\AgaP_AGAP004819

2 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\AT5G42560

9 of 13

Yes

Atha\HVA22H

9 of 13

Yes

Atha\HVA22G

8 of 13

Yes

Atha\HVA22J

8 of 13

Yes

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

1 of 13

Yes

Atha\AT1G77815

1 of 13

Yes

Atha\AT2G46460

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\YOP1

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPBC30D10.09c

6 of 12

Yes

Spom\yop1

2 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:ReepA. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

6 of 13

4 of 13

4 of 13

4 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

spastic paraplegia 31, autosomal dominant

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

ReepA⁵⁴¹

model of hereditary spastic paraplegia

CEA with ReepB⁴⁸

(Oliva et al., 2020)

model of hereditary spastic paraplegia 31

CEA

(Napoli et al., 2019)

ReepA^Δ258

model of tauopathy

CEC with Hsap\MAPT^UAS.2N4R.cAa

(Appocher et al., 2014)

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

REEP2; receptor accessory protein 2

model of hereditary spastic paraplegia 72B

IEA

(FlyBase, 2019-)

model of hereditary spastic paraplegia 72A

IEA

(FlyBase, 2019-)

REEP1; receptor accessory protein 1

model of autosomal recessive distal hereditary motor neuronopathy 6

IEA

(FlyBase, 2019-)

model of autosomal dominant distal hereditary motor neuronopathy 12

IEA

(FlyBase, 2019-)

model of hereditary spastic paraplegia 31

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

ReepA^GD2168

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.2N4R.cAa

(Appocher et al., 2014)

ReepA^Δ258

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.2N4R.cAa

(Appocher et al., 2014)

ReepA^Δ275

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.2N4R.cAa

(Appocher et al., 2014)

ReepA^UAS.Tag:FLAG

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.2N4R.cAa, ReepA^Δ258, ReepA^Δ275

(Appocher et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

REEP2; receptor accessory protein 2

9 of 14

609347

REEP4; receptor accessory protein 4

9 of 14

609349

REEP1; receptor accessory protein 1

7 of 14

RECEPTOR EXPRESSION-ENHANCING PROTEIN 1; REEP1

REEP3; receptor accessory protein 3

6 of 14

609348

REEP5; receptor accessory protein 5

3 of 14

125265

REEP6; receptor accessory protein 6

3 of 14

609346

RETINITIS PIGMENTOSA 77; RP77

retinitis pigmentosa 77

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

ReepA

Hsap\REEP1

(Appocher et al., 2014)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

ReepA - orb2

pull down, western blot

(Mastushita-Sakai et al., 2010)

protein-protein

Physical Interaction

Assay

References

ReepA - Ada3

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Atac1

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Atac2

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Chrac-14

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Gcn5

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Hcf

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Hsp23

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - MBD-R2

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Mocs2B

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - PolE4

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Rcd1

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Sgf29

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Vap33

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - Yeats2

experimental knowledge based

(Guruharsha et al., 2011)

ReepA - wds

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rtnl1

enhanceable

ReepA|ReepB

(Yalçın et al., 2017)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261564

MIST (protein-protein) - An integrated Molecular Interaction Database

37643

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-101

Cytogenetic map

59B6-59B6

Sequence location

2R:22,925,107..22,932,044 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

59B6-59B6

Limits computationally determined from genome sequence between P{PZ}Nup214¹⁰⁴⁴⁴ and P{PZ}l(2)06496⁰⁶⁴⁹⁶&P{lacW}l(2)k09913^k09913

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-101

(FlyBase, 2016)

2-106.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

91391

w^*; ReepA⁵⁴¹

93602

w^*; ReepA^Δ258

93603

w^*; ReepA^Δ275

77905

w^*; M{ReepA-GFP.1}ZH-86Fb

77906

w^*; M{ReepA-GFP.2}ZH-86Fb

93702

w^*; M{UAS-ReepA.RS}ZH-86Fa

43663

w^*; P{GSV1}ReepA^EP-1153

84207

y¹ v¹; M{WKO.P3-G9}ZH-86Fb

FlyORF

F001296

M{UAS-ReepA.ORF}ZH-86Fb

F001203

M{UAS-ReepA.ORF.3xHA}ZH-86Fb

VDRC

v21114

w¹¹¹⁸ P{GD10021}v21114

v39474

w¹¹¹⁸; P{GD2168}v39474

More stocks available...

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (125)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261564

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261564

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Appocher et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Area matching Drosophila ESTs AA201303 and AA541066.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG30190 CG30193

(FlyBase Genome Annotators, 2010)

Source for merge of: CG30193 BcDNA:RE29641

(FlyBase, 1996-)

Source for merge of: CG30193 anon-WO0118547.113

(FlyBase, 1996-)

Source for merge of: CG30193 BcDNA:LD42159

(FlyBase, 1996-)

Additional comments

Annotations CG30190 and CG30193 merged as CG42678 in release 5.25 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Source for merge of CG30193 BcDNA:RE29641 was a shared cDNA ( date:030728 ).

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

Source for merge of CG30193 anon-WO0118547.113 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Source for merge of CG30193 BcDNA:LD42159 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Reep1 CG42678

(Appocher et al., 2014)

Source for identity of: ReepA Reep1

(Yalçın et al., 2017)

Nomenclature comments

FlyBase curator comment: Renamed Reep1 to ReepA due to orthology to four mammalian genes (REEP1-REEP4), rather than solely REEP1.

(Yalçın et al., 2017)

Etymology

The gene is named 'ReepA' due to orthology to four mammalian REEP genes (REEP1-REEP4).

(Yalçın et al., 2017)

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

BcDNA:LD42159

BcDNA:RE29641

CG30190

(FlyBase Genome Annotators, 2007)

CG30193

(Schertel et al., 2013, Mastushita-Sakai et al., 2010, FlyBase Genome Annotators, 2007)

CG42678

(Yalçın et al., 2017, Hosono et al., 2015, Appocher et al., 2014, de Celis et al., 2013.9.11, Ni et al., 2011.7.19, FlyBase Genome Annotators, 2010)

CG9848

(Oliver, 2001.8.16)

D-reep1

(Appocher et al., 2014)

REEP1

(Gumeni et al., 2021)

REEPA

(Song et al., 2022)

Reep1

(Meltzer, 2019-, Meltzer et al., 2019, Bussmann and Storkebaum, 2017, Yalçın et al., 2017)

ReepA

(Praschberger et al., 2023, Lindsey et al., 2021, Oliva et al., 2020, Napoli et al., 2019, Gene Disruption Project members, 2018-, Yalçın et al., 2017)

anon-WO0118547.113

reep1

(Goel et al., 2019, Appocher et al., 2014)

Name Synonyms

REEP1 homolog

(Appocher et al., 2014)

REEP1 ortholog

(Giong et al., 2021)

Receptor expression enhancing protein 1

Receptor expression enhancing protein A

Secondary FlyBase IDs

FBgn0050193
FBgn0062236
FBgn0062456
FBgn0064893
FBgn0050190
FBgn0034799

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 103 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37643

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4JCU3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4JCU3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261564

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37643/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261564

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261564

InterPro - A database of protein families, domains and functional sites

TB2/DP1/HVA22

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42678

MARRVEL_MODEL - MARRVEL (model organism gene)

37643

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261564

DroID - A comprehensive database of gene and protein interactions.

FBgn0261564

DRSC - Results frm RNAi screens

FBgn0261564

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261564

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031982

MIST (protein-protein) - An integrated Molecular Interaction Database

37643

References (56)

The following external sites may use different assemblies or annotations than FlyBase.

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