FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rtnl1GD15707
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General Information
Symbol
Dmel\Rtnl1GD15707
Species
D. melanogaster
Name
FlyBase ID
FBal0208429
Feature type
allele
Associated gene
Dmel\Rtnl1
Associated Insertion(s)
Carried in Construct
P{GD15707}
Also Known As
UAS-Rtnl1-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD15707}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD15707
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hereditary spastic paraplegia
      CEA
      (Fowler and O'Sullivan, 2016)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  hereditary spastic paraplegia
      is ameliorated by Drp1UAS.cDb
      (Fowler and O'Sullivan, 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Rtnl1GD15707 under the control of either Scer\GAL4da.G32 or Scer\GAL4nSyb.PS results in a more rapid age-progressive decline in climbing abilities of adult flies and with the Scer\GAL4da.G32-driven expression also a mild decrease in their lifespan compared to controls. Expression under the Scer\GAL4RapGAP1-OK6 driver leads to defects in mitochondrial morphology (the mitochondria are abnormally elongated) in the distal portions of longer posterior (synapsing at segment 7) motor neuron axons.

      (Fowler and O'Sullivan, 2016)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The abnormal elongated morphology of mitochondria in the distal portions of long posterior (synapsing at segment 7) motor neurons axons observed in third instar larvae expressing Rtnl1GD15707 (under the Scer\GAL4RapGAP1-OK6 driver) as well the rapid age-progressive decline in climbing abilities in Rtnl1GD15707-expressing adults (using the Scer\GAL4nSyb.PS driver) is rescued by co-expression of Drp1Scer\UAS.cDb (without compromising adult lifespan).

      (Fowler and O'Sullivan, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rtnl1GD15707
      Name Synonyms
      Secondary FlyBase IDs
        References (7)