FlyBase Allele Report: Dmel\aln[Δ-Gal4]

General Information

Symbol

Dmel\aln^Δ-Gal4

Species

D. melanogaster

Name

FlyBase ID

FBal0391662

Feature type

allele

Associated gene

Dmel\aln

Associated Insertion(s)

TI{2A-GAL4}aln^Δ-Gal4

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele

(Shekhar et al., 2023)

Mutagen

CRISPR/Cas9

(Shekhar et al., 2023)

Progenitor genotype

Associated Insertion(s)

TI{2A-GAL4}aln^Δ-Gal4

Cytology

Description

The majority of the aln coding sequence is replaced with a self-cleaving T2A peptide and GAL4.

(Shekhar et al., 2023)

Allele components

Component

Use(s)

Inserted element

TI{2A-GAL4}

promoter trap

Encoded product / tool

GAL4

binary expression system - driver

Also carries

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3L:994,313..995,549 [+]

Comment:

DNA encoding the Aln amino acids 63 to the C-terminus ( 3L:994313..995549 ) is deleted and replaced by DNA encoding T2A-Gal4.

(Kramer, 2023.11.19)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | adult stage | light conditional

(Shekhar et al., 2023)

abnormal sleep | adult stage

(Shekhar et al., 2023)

Phenotype Manifest In

retina | adult stage | light conditional

(Shekhar et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

aln^Δ-Gal4 has abnormal neurophysiology | adult stage | light conditional phenotype, suppressible by Scer\GAL4^aln.Δ/Hsap\DIPK1C^{WT.UAS.Tag:FLAG}

(Shekhar et al., 2023)

aln^Δ-Gal4 has abnormal neurophysiology | adult stage | light conditional phenotype, suppressible by Scer\GAL4^aln.Δ/Hsap\DIPK1C^{D297A.UAS.Tag:FLAG}

(Shekhar et al., 2023)

NOT suppressed by

Statement

Reference

aln^Δ-Gal4 has abnormal neurophysiology | adult stage | light conditional phenotype, non-suppressible by Scer\GAL4^aln.Δ/CG11170^UAS.Tag:FLAG

(Shekhar et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

aln^Δ-Gal4 has retina | adult stage | light conditional phenotype, suppressible by Scer\GAL4^aln.Δ/Hsap\DIPK1C^{WT.UAS.Tag:FLAG}

(Shekhar et al., 2023)

aln^Δ-Gal4 has retina | adult stage | light conditional phenotype, suppressible by Scer\GAL4^aln.Δ/Hsap\DIPK1C^{D297A.UAS.Tag:FLAG}

(Shekhar et al., 2023)

NOT suppressed by

Statement

Reference

aln^Δ-Gal4 has retina | adult stage | light conditional phenotype, non-suppressible by Scer\GAL4^aln.Δ/CG11170^UAS.Tag:FLAG

(Shekhar et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

aln^Δ-Gal4 is rescued by Scer\GAL4^aln.Δ/aln^UAS.Tag:FLAG

(Shekhar et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

aln^Δ-Gal4

(Shekhar et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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