FlyBase Allele Report: Dmel\Uba5[KO]

General Information

Symbol

Dmel\Uba5^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0397842

Feature type

allele

Associated gene

Dmel\Uba5

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

loss of function allele

(Pan et al., 2023)

Mutagen

CRISPR/Cas9

(Pan et al., 2023)

Progenitor genotype

P{TKO.GS04694}

(Pan et al., 2023)

Cytology

Description

11bp deletion in Uba5.

(Pan et al., 2023)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:11,483,817..11,483,827 [+]

Comment:

11bp deletion in the Uba5 coding region beginning in codon R55.

(Pan et al., 2023)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of developmental and epileptic encephalopathy 44

CEA

(Pan et al., 2023)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage (with Uba5^{CR00497-TG4.2})

(Pan et al., 2023)

lethal - all die during embryonic stage | female | recessive

(Pan et al., 2023)

lethal - all die during embryonic stage | male

(Pan et al., 2023)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Uba5^KO has lethal - all die during embryonic stage | male phenotype, suppressible by Scer\GAL4^da.PU/Hsap\UBA5^UAS.cBa

(Pan et al., 2023)

Uba5^KO has lethal - all die during embryonic stage | male phenotype, suppressible by Scer\GAL4^Act5C.PI/Hsap\UBA5^UAS.cBa

(Pan et al., 2023)

NOT suppressed by

Statement

Reference

Uba5^KO has lethal - all die during embryonic stage | male phenotype, non-suppressible by Scer\GAL4^apolpp.PB/Hsap\UBA5^UAS.cBa

(Pan et al., 2023)

Uba5^KO has lethal - all die during embryonic stage | male phenotype, non-suppressible by Scer\GAL4^repo/Hsap\UBA5^UAS.cBa

(Pan et al., 2023)

Uba5^KO has lethal - all die during embryonic stage | male phenotype, non-suppressible by Scer\GAL4^Mef2.PR/Hsap\UBA5^UAS.cBa

(Pan et al., 2023)

Uba5^KO has lethal - all die during embryonic stage | male phenotype, non-suppressible by Hsap\UBA5^UAS.cBa/Scer\GAL4^elav.PLu

(Pan et al., 2023)

Uba5^KO has lethal - all die during embryonic stage | male phenotype, non-suppressible by Scer\GAL4^repo/Hsap\UBA5^UAS.cBa/Scer\GAL4^elav.PLu

(Pan et al., 2023)

Other

Statement

Reference

Hsap\UBA5^UAS.cBa, Scer\GAL4^Act5C.PI, Uba5^KO/Uba5[+] has viable | female phenotype

(Pan et al., 2023)

Hsap\UBA5^UAS.cBa, Scer\GAL4^da.PU, Uba5^KO/Uba5[+] has viable | female phenotype

(Pan et al., 2023)

Hsap\UBA5^UAS.cBa, Scer\GAL4^elav.PLu, Uba5^KO/Uba5[+] has viable | female phenotype

(Pan et al., 2023)

Hsap\UBA5^UAS.cBa, Scer\GAL4^apolpp.PB, Uba5^KO/Uba5[+] has viable | female phenotype

(Pan et al., 2023)

Hsap\UBA5^UAS.cBa, Scer\GAL4^repo, Uba5^KO/Uba5[+] has viable | female phenotype

(Pan et al., 2023)

Hsap\UBA5^UAS.cBa, Scer\GAL4^Mef2.PR, Uba5^KO/Uba5[+] has viable | female phenotype

(Pan et al., 2023)

Hsap\UBA5^UAS.cBa, Scer\GAL4^elav.PLu, Scer\GAL4^repo, Uba5^KO/Uba5[+] has viable | female phenotype

(Pan et al., 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Uba5^KO

(Pan et al., 2023)

Uba5^p.R55PfsX87

(Pan et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close