FlyBase Allele Report: Dmel\GCS1[Sz]

General Information

Symbol

Dmel\GCS1^Sz

Species

D. melanogaster

Name

FlyBase ID

FBal0404373

Feature type

allele

Associated gene

Dmel\GCS1

Associated Insertion(s)

Carried in Construct

Also Known As

tu-Sz^ts, tuSz¹, tu(1)Sz¹, tu(1)Sz^ts

Key Links

Genomic Maps

JBrowse

Allele class

heat sensitive loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

heat sensitive loss of function allele

(Mortimer et al., 2021)

Mutagen

ethyl methanesulfonate

(Mortimer et al., 2021, Rizki and Rizki, 1980)

Progenitor genotype

Cytology

Description

C to T transition 35bp upstream of the GCS1 transcription start site.

(Mortimer et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,348,036..11,348,036 [-]

Nucleotide change:

C11348036T

Reported nucleotide change:

C?T

Comment:

C to T transition 35bp upstream of the GCS1 transcription start site.

(Mortimer et al., 2021)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

GCS1^Sz, hop^Sz has visible | larval stage | heat sensitive phenotype, suppressible | partially by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has visible | heat sensitive phenotype, suppressible | partially by Stat92E^JF01266/Scer\GAL4^msn.F9mo

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has melanotic mass phenotype | larval stage | heat sensitive phenotype, suppressible | partially by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has melanotic mass phenotype | heat sensitive phenotype, suppressible | partially by Stat92E^JF01266/Scer\GAL4^msn.F9mo

(Mortimer et al., 2021)

Other

Statement

Reference

GCS1^KK102814, GCS1^Sz, Scer\GAL4^C833, hop^Sz has melanotic mass phenotype phenotype

(Mortimer et al., 2021)

GCS1^KK102814, GCS1^Sz, Scer\GAL4^C833, hop^Sz has visible | adult stage phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has visible | adult stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has melanotic mass phenotype | larval stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has visible | larval stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has melanotic mass phenotype | adult stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has melanotic mass phenotype | P-stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has abnormal immune response | larval stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has visible | P-stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has abnormal cell number | larval stage phenotype

(Mortimer et al., 2021)

GCS1^E/GCS1^Sz, hop^Sz has visible phenotype

(Mortimer et al., 2021)

GCS1^E/GCS1^Sz, hop^Sz has melanotic mass phenotype phenotype

(Mortimer et al., 2021)

GCS1^Sz/GCS1^A, hop^Sz has visible phenotype

(Mortimer et al., 2021)

GCS1^Sz/GCS1^A, hop^Sz has melanotic mass phenotype phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has melanotic mass phenotype | heat sensitive phenotype

(Zhimulev et al., 1987)

GCS1^Sz, hop^Sz has melanotic mass phenotype | third instar larval stage | heat sensitive phenotype

(Rizki and Rizki, 1980)

Phenotype Manifest In

Suppressed by

Statement

Reference

GCS1^Sz, hop^Sz has embryonic/larval fat body | larval stage | heat sensitive phenotype, suppressible | partially by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has embryonic/larval fat body | heat sensitive phenotype, suppressible | partially by Stat92E^JF01266/Scer\GAL4^msn.F9mo

(Mortimer et al., 2021)

Other

Statement

Reference

GCS1^Sz/GCS1^A, hop^Sz has fat body phenotype

(Mortimer et al., 2021)

GCS1^KK102814, GCS1^Sz, Scer\GAL4^C833, hop^Sz has adult fat body | adult stage phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has embryonic/larval lymph gland | larval stage phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has embryonic/larval plasmatocyte | larval stage phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has embryonic/larval crystal cell | larval stage | decreased number phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has embryonic/larval fat body | larval stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has adult fat body | adult stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has adult fat body | P-stage | heat sensitive phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has lamellocyte | increased number | larval stage phenotype

(Mortimer et al., 2021)

GCS1^E/GCS1^Sz, hop^Sz has fat body phenotype

(Mortimer et al., 2021)

GCS1^Sz, hop^Sz has melanotic mass | heat sensitive phenotype

(Zhimulev et al., 1987)

GCS1^Sz, hop^Sz has melanotic mass | third instar larval stage | heat sensitive phenotype

(Rizki and Rizki, 1980)

GCS1^Sz, hop^Sz has embryonic/larval fat body region 5 | third instar larval stage | heat sensitive phenotype

(Rizki and Rizki, 1980)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5834

GCS1^Sz hop^Sz

Notes on Origin

Discoverer

Separable from: hop^Sz.

(Mortimer et al., 2021)

The temperature-sensitive self-encapsulation phenotype (melanization of posterior fat body tissue) of the 'tu(1)Sz[1]' mutant strain is caused by two distinct mutations, a dominant gain-of-function mutation in hop (hop^Sz) and a conditional, recessive loss-of-function mutation in GCS1 (GCS1^Sz).

(Mortimer et al., 2021)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

GCS1^Sz

(Mortimer et al., 2021)

Tu-Sz^ts

(Brennan and Anderson, 2004)

tu(1)Sz

(Mortimer et al., 2013)

tu(1)Sz¹

(Yang et al., 2019, Rizki and Rizki, 1980)

tu(1)Sz^ts

(Lavine and Strand, 2002, Perez-Chiesa, 1999, Zhimulev et al., 1987, Rizki et al., 1985)

tu-Sz(ts)

(Rizki et al., 1983)

tu-Sz^ts

(Dearolf, 1998, Rizki and Rizki, 1991, Rizki and Rizki, 1990, Rizki and Rizki, 1990)

tuSz¹

(Hayman et al., 2025, Mortimer et al., 2021)

Name Synonyms

tumor (1) Sz

Secondary FlyBase IDs

FBal0017210

References (15)

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