FB2026_02 , released June 18, 2026
Allele: Dmel\Cdk1as2
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General Information
Symbol
Dmel\Cdk1as2
Species
D. melanogaster
Name
FlyBase ID
FBal0404913
Feature type
allele
Associated gene
Dmel\Cdk1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Loyer et al., 2024)
gene targeting by homologous recombination
(Loyer et al., 2024)
Progenitor genotype
Cytology
Description

Amino acid replacement: F80A.

(Loyer et al., 2024)

In addition to the F80A, there is a silent mutation (CTA to TTG) at codon L83.

(Loyer et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2L:10,385,553..10,385,555 [-]
Nucleotide change:

TTT10385555GCC

Reported nucleotide change:

TTT?GCC

Amino acid change:

F80A | Cdk1-PA

Reported amino acid change:

F80A

Comment:

A silent mutation at L83 (CTA to TTG) was also introduced in this strain.

(Loyer et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Cdk1as2, bazΔLB.Ubi.EGFP, baz815-8 has abnormal cell polarity | larval stage | chemical conditional phenotype

      (Loyer et al., 2024)

      Cdk1as2, bazΔOD.Ubi.EGFP, baz815-8 has abnormal cell polarity | larval stage | chemical conditional phenotype

      (Loyer et al., 2024)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Cdk1as2, bazΔLB.Ubi.EGFP, baz815-8 has larval neuroblast | chemical conditional phenotype

      (Loyer et al., 2024)

      Cdk1as2, bazΔLB.Ubi.EGFP, baz815-8 has apical part of cell | larval stage | chemical conditional phenotype

      (Loyer et al., 2024)

      Cdk1as2, bazΔOD.Ubi.EGFP, baz815-8 has larval neuroblast | chemical conditional phenotype

      (Loyer et al., 2024)

      Cdk1as2, bazΔOD.Ubi.EGFP, baz815-8 has apical part of cell | larval stage | chemical conditional phenotype

      (Loyer et al., 2024)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cdk1as2
      cdk1as2
      (Loyer et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)