FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fhGAAs
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General Information
Symbol
Dmel\fhGAAs
Species
D. melanogaster
Name
FlyBase ID
FBal0405292
Feature type
allele
Associated gene
Dmel\fh
Associated Insertion(s)
TI{TI}fhGAAs
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Jullian et al., 2024)
Mutagen
CRISPR/Cas9
(Jullian et al., 2024)
gene targeting by homologous recombination
(Jullian et al., 2024)
Progenitor genotype
Associated Insertion(s)
TI{TI}fhGAAs
Cytology
Description

An GAA triplet-repeat from the first intron of the human Hsap\FXN gene, with a GAA repeat length of 42 units, has been inserted into the intron of the orthologous D. melanogaster fh gene. The Hsap\FXN sequence includes sequence from the human first intron flanking each side of the GAA expansion (157bp upstream and 87bp downstream sequence).

(Jullian et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Friedreich ataxia 1
      CEA
      (Jullian et al., 2024)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Friedreich ataxia 1
      is ameliorated by TspoUAS.cRa
      (Jullian et al., 2024)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Jullian et al., 2024)

      The number of GAA repeats represented in this allele falls below the pathogenic repeat range in human (>35 repeats).

      (FlyBase curators, 2019-)
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      fhGAAs
      Name Synonyms
      Secondary FlyBase IDs
        References (2)