FlyBase Allele Report: Dmel\Nsun2[5-2]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Nsun2^5-2

General Information

Symbol

Dmel\Nsun2^5-2

Species

D. melanogaster

Name

FlyBase ID

FBal0407402

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

(Gonskikh et al., 2025)

Progenitor genotype

Cytology

Description

874bp deletion (the deleted sequence is replaced with GACA) within Nsun2.

(Gonskikh et al., 2025)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

X:4,112,585..4,113,458 [-]

Comment:

874bp deletion (the deleted sequence is replaced with GACA) within Nsun2.

Inserted_sequence:

GACA

(Gonskikh et al., 2025)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal recessive intellectual developmental disorder 5

CEA

(Gonskikh et al., 2025)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of autosomal recessive intellectual developmental disorder 5

is ameliorated by Hsap\NSUN2^UAS.Tag:FLAG

(Gonskikh et al., 2025)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | adult stage

(Gonskikh et al., 2025)

decreased rate of adult locomotory behavior

(Gonskikh et al., 2025)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Nsun2^5-2 has decreased rate of adult locomotory behavior phenotype, non-enhanceable by Scer\GAL4^elav.PU/Hsap\NSUN2^{ΔIDR.UAS.Tag:FLAG}

(Gonskikh et al., 2025)

Nsun2^5-2 has decreased rate of adult locomotory behavior phenotype, non-enhanceable by Hsap\NSUN2^{G679R.UAS.Tag:FLAG}/Scer\GAL4^elav.PU

(Gonskikh et al., 2025)

Suppressed by

Statement

Reference

Nsun2^5-2 has abnormal behavior | adult stage phenotype, suppressible | partially by Scer\GAL4^elav.PU/Hsap\NSUN2^UAS.Tag:FLAG

(Gonskikh et al., 2025)

Nsun2^5-2 has abnormal behavior | adult stage phenotype, suppressible | partially by Scer\GAL4^elav.PU/Hsap\NSUN2^{ΔIDR.UAS.Tag:FLAG}

(Gonskikh et al., 2025)

Nsun2^5-2 has decreased rate of adult locomotory behavior phenotype, suppressible by Scer\GAL4^elav.PU/Hsap\NSUN2^UAS.Tag:FLAG

(Gonskikh et al., 2025)

NOT suppressed by

Statement

Reference

Nsun2^5-2 has decreased rate of adult locomotory behavior phenotype, non-suppressible by Scer\GAL4^elav.PU/Hsap\NSUN2^{ΔIDR.UAS.Tag:FLAG}

(Gonskikh et al., 2025)

Nsun2^5-2 has decreased rate of adult locomotory behavior phenotype, non-suppressible by Hsap\NSUN2^{G679R.UAS.Tag:FLAG}/Scer\GAL4^elav.PU

(Gonskikh et al., 2025)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Nsun2^5-2

(Gonskikh et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections