FlyBase Allele Report: Dmel\dpp[RNAi.UAS.cUa]

General Information

Symbol

Dmel\dpp^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407500

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

P{UAS-dpp.RNAi.U}

Also Known As

UAS-dppRNAi, UAS-dpp RNAi

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-dpp.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of a dpp RNAi construct.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dpp

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of juvenile polyposis syndrome

CEA

(Guo et al., 2013)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^A9

(Wang et al., 2018)

hyperplasia, with Scer\GAL4^GMR13B09

(Guo et al., 2013)

lethal - all die before end of pupal stage, with Scer\GAL4^jhamt.PH

(Huang et al., 2011)

visible, with Scer\GAL4^C-765

(Chauhan et al., 2013)

visible | adult stage, with Scer\GAL4^A9

(Wang et al., 2018)

Phenotype Manifest In

adult posterior midgut epithelium, with Scer\GAL4^GMR13B09

(Guo et al., 2013)

wing, with Scer\GAL4^A9

(Wang et al., 2018)

wing vein, with Scer\GAL4^A9

(Wang et al., 2018)

wing vein L2, with Scer\GAL4^C-765

(Chauhan et al., 2013)

wing vein L5, with Scer\GAL4^C-765

(Chauhan et al., 2013)

Detailed Description

Statement

Reference

Expression of dpp^TRiP.cUa under the control of Scer\GAL4^A9 severely depletes wing vein tissue and reduces wing size.

(Wang et al., 2018)

Modest expression of dpp^{dsRNA.Scer\UAS.cUa} in the wing disc under the control of Scer\GAL4^C-765 results in shortened wing veins L2 and L5 at low penetrance.

(Chauhan et al., 2013)

Expression of dpp^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^GMR13B09 for eight days results in a dramatic increase in mitotic cell numbers as compared with wild-type.

(Guo et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^C-765, dpp^RNAi.UAS.cUa has visible phenotype, enhanceable by Lpt^RNAi.UAS, Scer\GAL4^C-765

(Chauhan et al., 2013)

Suppressed by

Statement

Reference

Scer\GAL4^A9, dpp^RNAi.UAS.cUa has abnormal size | adult stage phenotype, suppressible | partially by Scer\GAL4^A9/anchor^GD3613

(Wang et al., 2018)

Scer\GAL4^A9, dpp^RNAi.UAS.cUa has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^A9/anchor^GD3613

(Wang et al., 2018)

Suppressor of

Statement

Reference

dpp^RNAi.UAS.cUa, Scer\GAL4^C-765 is a suppressor | partially of visible phenotype of Lpt^UAS.Tag:HA, Scer\GAL4^C-765

(Chauhan et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^C-765, dpp^RNAi.UAS.cUa has wing vein L2 phenotype, enhanceable by Lpt^RNAi.UAS, Scer\GAL4^C-765

(Chauhan et al., 2013)

Scer\GAL4^C-765, dpp^RNAi.UAS.cUa has wing vein L5 phenotype, enhanceable by Lpt^RNAi.UAS, Scer\GAL4^C-765

(Chauhan et al., 2013)

Suppressed by

Statement

Reference

Scer\GAL4^A9, dpp^RNAi.UAS.cUa has wing phenotype, suppressible | partially by Scer\GAL4^A9/anchor^GD3613

(Wang et al., 2018)

NOT suppressed by

Statement

Reference

Scer\GAL4^A9, dpp^RNAi.UAS.cUa has wing vein phenotype, non-suppressible by Scer\GAL4^A9/anchor^GD3613

(Wang et al., 2018)

Suppressor of

Statement

Reference

Scer\GAL4^A9/dpp^RNAi.UAS.cUa is a suppressor | partially of wing phenotype of Scer\GAL4^A9, anchor^GD3613

(Wang et al., 2018)

dpp^RNAi.UAS.cUa, Scer\GAL4^C-765 is a suppressor | partially of wing vein | ectopic phenotype of Lpt^UAS.Tag:HA, Scer\GAL4^C-765

(Chauhan et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The increased wing size phenotype of adults expressing anchor^GD3613 under the control of Scer\GAL4^A9 is suppressed by addition of dpp^TRiP.cUa, to the extent that it is decreased compared to flies with Scer\GAL4^A9 driver alone.

Additional expression of anchor^GD3613 in flies expressing dpp^TRiP.cUa under the control of Scer\GAL4^A9 does not rescue the reduction in wing vein tissue, but does slightly rescue wing size.

(Wang et al., 2018)

Simultaneous expression of dpp^{dsRNA.Scer\UAS.cUa} and Lpt^{dsRNA.Scer\UAS}, both under the control of Scer\GAL4^C-765, results in further shortening of the wing veins.

Simultaneous expression of Lpt^{Scer\UAS.T:Ivir\HA1} and dpp^{dsRNA.Scer\UAS.cUa} (both under the control of Scer\GAL4^C-765) results in suppression of both the incomplete vein phenotypes observed upon dpp^{dsRNA.Scer\UAS.cUa}-expression as well as the ectopic vein phenotypes observed upon Lpt^{Scer\UAS.T:Ivir\HA1} overexpression.

(Chauhan et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dpp^RNAi.UAS.cUa

dpp^TRiP.cUa

dpp^{dsRNA.Scer\UAS.cUa}

dpp^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

FBal0248856
FBal0341674

References (13)

Report Sections

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