FlyBase Allele Report: Dmel\park[YCTC]

General Information

Symbol

Dmel\park^YCTC

Species

D. melanogaster

Name

FlyBase ID

FBal0409307

Feature type

allele

Associated gene

Dmel\park

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Ham et al., 2025)

gene targeting by homologous recombination

(Ham et al., 2025)

Progenitor genotype

Cytology

Description

Amino acid replacement: Y344C.

(Ham et al., 2025)

The Y344 and

(Ham et al., 2025)

Amino acid replacement: T469C.

(Ham et al., 2025)

T469 residues in endogenous park are substituted with cysteines.

(Ham et al., 2025)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage

(Ham et al., 2025)

decreased rate of adult locomotory behavior

(Ham et al., 2025)

short lived

(Ham et al., 2025)

Phenotype Manifest In

adult dopaminergic neuron | decreased number

(Ham et al., 2025)

dopaminergic PPL1 neuron | decreased number

(Ham et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

park^YCTC has decreased rate of adult locomotory behavior phenotype, enhanceable by Scer\GAL4^ple.PF/Fum1^GD11215

(Ham et al., 2025)

park^YCTC has decreased cell number | adult stage phenotype, enhanceable by Scer\GAL4^ple.PF/Fum1^GD11215

(Ham et al., 2025)

Suppressed by

Statement

Reference

park^YCTC has decreased rate of adult locomotory behavior phenotype, suppressible | partially by porin^NIG.6647R/Scer\GAL4^ple.PF

(Ham et al., 2025)

park^YCTC has decreased rate of adult locomotory behavior phenotype, suppressible | partially by SdhD^NIG.10219R/Scer\GAL4^ple.PF

(Ham et al., 2025)

park^YCTC has decreased cell number | adult stage phenotype, suppressible by porin^NIG.6647R/Scer\GAL4^ple.PF

(Ham et al., 2025)

park^YCTC has decreased cell number | adult stage phenotype, suppressible by SdhD^NIG.10219R/Scer\GAL4^ple.PF

(Ham et al., 2025)

Phenotype Manifest In

Enhanced by

Statement

Reference

park^YCTC has dopaminergic PPL1 neuron | decreased number phenotype, enhanceable by Scer\GAL4^ple.PF/Fum1^GD11215

(Ham et al., 2025)

park^YCTC has adult dopaminergic neuron | decreased number phenotype, enhanceable by Scer\GAL4^ple.PF/Fum1^GD11215

(Ham et al., 2025)

Suppressed by

Statement

Reference

park^YCTC has adult dopaminergic neuron | decreased number phenotype, suppressible by porin^NIG.6647R/Scer\GAL4^ple.PF

(Ham et al., 2025)

park^YCTC has adult dopaminergic neuron | decreased number phenotype, suppressible by SdhD^NIG.10219R/Scer\GAL4^ple.PF

(Ham et al., 2025)

park^YCTC has dopaminergic PPL1 neuron | decreased number phenotype, suppressible by SdhD^NIG.10219R/Scer\GAL4^ple.PF

(Ham et al., 2025)

park^YCTC has dopaminergic PPL1 neuron | decreased number phenotype, suppressible by porin^NIG.6647R/Scer\GAL4^ple.PF

(Ham et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

park^YCTC

parkin^YCTC

(Ham et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close