FlyBase Allele Report: Dmel\IbinB[KO]

General Information

Symbol

Dmel\IbinB^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0410987

Feature type

allele

Associated gene

Dmel\IbinB

Associated Insertion(s)

TI{TI}IbinB^KO

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Maasdorp et al., 2026)

Mutagen

CRISPR/Cas9

(Maasdorp et al., 2026)

Progenitor genotype

Associated Insertion(s)

TI{TI}IbinB^KO

Cytology

Description

Precise deletion of IbinB protein-coding sequence and replacement with a 3xP3RFP(Unk) marker cassette flanked by loxP sites.

(Maasdorp et al., 2026)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Maasdorp et al., 2026)

increased cell number | larval stage

(Maasdorp et al., 2026)

melanotic necrosis | adult stage

(Maasdorp et al., 2026)

short lived

(Maasdorp et al., 2026)

visible | adult stage

(Maasdorp et al., 2026)

Phenotype Manifest In

embryonic/larval hemocyte | increased number | larval stage

(Maasdorp et al., 2026)

embryonic/larval plasmatocyte | increased number | larval stage

(Maasdorp et al., 2026)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

IbinA^KO, IbinB^KO has partially lethal - majority die phenotype

(Maasdorp et al., 2026)

IbinA^KO, IbinB^KO has abnormal immune response phenotype

(Maasdorp et al., 2026)

IbinA^KO, IbinB^KO has melanotic necrosis | P-stage phenotype

(Maasdorp et al., 2026)

IbinA^KO, IbinB^KO has short lived phenotype

(Maasdorp et al., 2026)

IbinA^KO, IbinB^KO has visible | adult stage phenotype

(Maasdorp et al., 2026)

IbinA^KO, IbinB^KO has increased cell number | larval stage phenotype

(Maasdorp et al., 2026)

IbinA^KO, IbinB^KO has melanotic necrosis | adult stage phenotype

(Maasdorp et al., 2026)

IbinA^KO, IbinB^KO has visible | P-stage phenotype

(Maasdorp et al., 2026)

Phenotype Manifest In

Other

Statement

Reference

IbinA^KO, IbinB^KO has adult tracheal system phenotype

(Maasdorp et al., 2026)

IbinA^KO, IbinB^KO has embryonic/larval hemocyte | increased number | larval stage phenotype

(Maasdorp et al., 2026)

IbinA^KO, IbinB^KO has embryonic/larval plasmatocyte | increased number | larval stage phenotype

(Maasdorp et al., 2026)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

IbinB^KO

(Maasdorp et al., 2026)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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