FlyBase Allele Report: Dmel\Diap1[NIG.12284R]

General Information

Symbol

Dmel\Diap1^NIG.12284R

Species

D. melanogaster

Name

FlyBase ID

FBal0414115

Feature type

allele

Associated gene

Dmel\Diap1

Associated Insertion(s)

Carried in Construct

P{NIG.12284R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21, Oshima, 2006)

Progenitor genotype

Carried in construct

P{NIG.12284R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-12284R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | larval stage, with Scer\GAL4^en.PU

(Wada et al., 2021)

increased cell death | larval stage, with Scer\GAL4^nub.PU

(Wada et al., 2021)

Phenotype Manifest In

macrochaeta, with Scer\GAL4^sca-109-68

(Koto et al., 2009)

wing disc | larval stage, with Scer\GAL4^en.PU

(Wada et al., 2021)

wing disc | larval stage, with Scer\GAL4^nub.PU

(Wada et al., 2021)

Detailed Description

Statement

Reference

Expression of th^{dsRNA.cOa.Scer\UAS} in all four cells of the adult sensory organ, under the control of Scer\GAL4^sca-109-68, thereby resulting in a down-regulation of th, results in bristle loss, but sockets show normal development.

(Koto et al., 2009)

Expression of th^{dsRNA.cOa.Scer\UAS} under the control of Scer\GAL4^ap-md544 does not lead to an increase in the number of apoptotic cells observed in eye/antennal discs.

(Oshima, 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Diap1^NIG.12284R, Scer\GAL4^nub.PU has increased cell death | larval stage phenotype, enhanceable by RpS3[+]/RpS3^Plac92

(Wada et al., 2021)

Diap1^NIG.12284R, Scer\GAL4^en.PU has increased cell death | larval stage phenotype, enhanceable by RpS3[+]/RpS3^Plac92

(Wada et al., 2021)

Enhancer of

Statement

Reference

Diap1^NIG.12284R/Scer\GAL4^en.PU is an enhancer of increased cell death | larval stage phenotype of RpS3^Plac92

(Wada et al., 2021)

Diap1^NIG.12284R/Scer\GAL4^nub.PU is an enhancer of increased cell death | larval stage phenotype of RpS3^Plac92

(Wada et al., 2021)

Other

Statement

Reference

Diap1^NIG.12284R, RpS3^Plac92, Scer\GAL4^en.PU has visible | adult stage phenotype

(Wada et al., 2021)

Diap1^NIG.12284R, RpS3^Plac92, Scer\GAL4^en.PU has decreased size | adult stage phenotype

(Wada et al., 2021)

Diap1^NIG.12284R, RpS3^Plac92, Scer\GAL4^nub.PU has visible | adult stage phenotype

(Wada et al., 2021)

Diap1^NIG.12284R, RpS3^Plac92, Scer\GAL4^nub.PU has decreased size | adult stage phenotype

(Wada et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

Diap1^NIG.12284R, Scer\GAL4^nub.PU has wing disc | larval stage phenotype, enhanceable by RpS3[+]/RpS3^Plac92

(Wada et al., 2021)

Diap1^NIG.12284R, Scer\GAL4^en.PU has wing disc | larval stage phenotype, enhanceable by RpS3[+]/RpS3^Plac92

(Wada et al., 2021)

Enhancer of

Statement

Reference

Diap1^NIG.12284R/Scer\GAL4^en.PU is an enhancer of wing disc | larval stage phenotype of RpS3^Plac92

(Wada et al., 2021)

Diap1^NIG.12284R/Scer\GAL4^nub.PU is an enhancer of wing disc | larval stage phenotype of RpS3^Plac92

(Wada et al., 2021)

Suppressor of

Statement

Reference

Diap1^NIG.12284R, Scer\GAL4^sca.PU is a suppressor | partially of scutellar bristle phenotype of IKKε^DN.UAS, Scer\GAL4^sca.PU

(Otani et al., 2011)

Diap1^NIG.12284R, Scer\GAL4^ap-md544 is a suppressor of arista lateral phenotype of IKKε^DN.UAS, Scer\GAL4^ap-md544

(Oshima et al., 2006)

Other

Statement

Reference

Diap1^NIG.12284R, RpS3^Plac92, Scer\GAL4^en.PU has wing phenotype

(Wada et al., 2021)

Diap1^NIG.12284R, RpS3^Plac92, Scer\GAL4^nub.PU has wing phenotype

(Wada et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The excess branching of arista seen in flies that express ik2^DN.Scer\UAS under the control of Scer\GAL4^ap-md544 is suppressed by th^{dsRNA.cOa.Scer\UAS}.

(Oshima et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Diap1^NIG.12284R is rescued by Diap1^{PRAP.UAS.Venus}/Scer\GAL4^sca-109-68

(Koto et al., 2009)

Comments

The loss-of-bristle phentoype observed in th^{dsRNA.cOa.Scer\UAS}-Scer\GAL4^sca-109-68 flies is suppressed though expression of th^{N117K.H283Y.Scer\UAS.T:Avic\GFP-YFP.Venus}.

(Koto et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (1)

NIG-Fly

12284R-2

P{NIG.12284R}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

DAIP1^RNAi

(Oshima et al., 2006)

DIAP1^RNAi

(Otani et al., 2011)

Diap1^NIG.12284R

Diap1^RNAi.UAS.cOa

Diap1^{dsRNA.cOa.Scer\UAS}

Diap1^{dsRNA.cOa.UAS}

th^NIG.12284R

th^{dsRNA.cOa.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

FBal0271195
FBal0194834

References (7)

Report Sections

Open Close