FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: HETEROTRIMERIC G-PROTEIN SUBUNITS
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General Information
Name
HETEROTRIMERIC G-PROTEIN SUBUNITS
Species
D. melanogaster
Symbol
G-SUB
FlyBase ID
FBgg0000458
Date last reviewed
2016-01-26
Number of members
14
Description
Description
The Heterotrimeric G-proteins are composed of three types of subunit (Gα, Gβ and Gγ) and mediate many cellular signaling processes. The heterotrimeric G-protein subunits interact with G-protein-coupled receptors (GPCRs) at the plasma membrane. Upon GTP binding, Gα-GTP dissociates from the heterotrimer Gαβγ, then Gα and Gβγ act on their effectors. (Adapted from FBrf0183798, FBrf0209904 and PMID:18043707).
Notes on Group
Source Material
The HETEROTRIMERIC G-PROTEIN SUBUNITS Gene Group has been compiled using the following publication(s): Marygold, 2021.11.30, Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, and Colicelli, 2004 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
G protein-coupled receptor signaling pathway
Cellular Component
heterotrimeric G-protein complex
plasma membrane
Related Gene Groups
Component group(s)
HETEROTRIMERIC G-PROTEIN ALPHA SUBUNITS
HETEROTRIMERIC G-PROTEIN BETA SUBUNITS
HETEROTRIMERIC G-PROTEIN GAMMA SUBUNITS
Other related group(s)
G PROTEIN COUPLED RECEPTORS
Members (14)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
Heterotrimeric-G
HETEROTRIMERIC G-PROTEIN SUBUNITS
G-protein subunits
G-SUB
G SUBUNIT
Secondary FlyBase ID(s)
References (7)