Prototypical RNA polymerase C-terminal domain (CTD) family phosphatases dephosphorylate specific serine residues in the carboxyl-terminal tail of the RNA polymerase catalytic subunit, a feature essential for the reinitiation of transcription by the RNA polymerase. However, other members of this family have diversified to have other substrates, such as nuclear pore complex proteins. (Adapted from
FBrf0228712.)
