The Haloacid Dehalogenase (HAD) family members are hydrolases characterised by a conserved α/β-domain Rossmann fold-like domain and three additional domains: squiggle, flap and cap domains, that contribute to substrate specificity. HADs are aspartate-nucleophile hydrolases, using a aspartate residue for nucleophilic attack. The HAD protein phosphatase group is a collection of HADs that belong to subgroups that dephosphorylate proteins. (Adapted from
FBrf0228712).
