FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Complex: EXT1-EXT2 COMPLEX
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General Information
Name
EXT1-EXT2 COMPLEX
Species
D. melanogaster
Symbol
EXT1-EXT2
FlyBase ID
FBgg0001998
Date last reviewed
2024-08-07
Number of members
2
Description
Description
The EXT1-EXT2 complex is a heterodimer required for the elongation of heparan sulfate proteoglycan (HSPG) chains. HSPGs are implicated in regulating the signalling activities of secreted morphogen molecules including Wingless, Hedgehog and Decapentaplegic. Each protein monomer within the complex contains distinct glycosyltransferase domains with different activities. (Adapted from PMID:36593275 and FBrf0174560.)
Notes on Group
Source Material
The EXT1-EXT2 COMPLEX Gene Group has been compiled using the following publication(s): Han et al., 2004 .
Key Gene Ontology (GO) terms
Molecular Function
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
Biological Process
heparan sulfate proteoglycan biosynthetic process
Cellular Component
EXT1-EXT2 complex
Enzymatic activity
Enzyme name (EC)
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase (2.4.1.224)
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase (2.4.1.225)
Related Gene Groups
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
EXT1-EXT2
EXT1-EXT2 COMPLEX
Secondary FlyBase ID(s)
References (2)