FlyBase Gene Report: Dmel\nob

General Information

Symbol

Dmel\nob

Species

D. melanogaster

Name

no bridge

Annotation Symbol

Feature Type

gene

FlyBase ID

FBgn0002946

Gene Model Status

Unannotated

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Red Book
Interactive Fly

Function

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in response to pain

inferred from mutant phenotype

(Xu et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in adult walking behavior

traceable author statement

(Strauss, 2002)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

nob: no bridge (J.C. Hall)

Protocerebral bridge between left and right sides of adult brain seems disintegrated into two or more glomeruli; fiber number in interhemispheric commisure of white pupa reduced; learning is poor in "arena paradigm" tests of adults, using sugar and odorants (Heisenberg et al., 1985); larval learning test using electric shocks and odorants gave approximately half the normal score (Heisenberg, unpublished). Locomotor activity of mutant adults is abnormal (spontaneous walking speed, regarding forward strides of legs, is slow), and in flight, there is reduced frequency of flight starts, altered "object response" and reduced occurrences of "body saccades" (Heisenberg). Adults exhibit aberrant habituation of proboscis-extension reflex (Bouhouche and Vaysse, 1991).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transcript Data

Annotated Transcripts

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Polypeptides with Identical Sequences

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nob using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\nob in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\nob

View exonic expression by tissue for Dmel\nob

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of nob

Transgenic constructs containing regulatory region of nob

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(1)HC244

(Varnam et al., 1996, Strauss et al., 1992)

Gene not disrupted in

Df(1)A113

(Strauss et al., 1992)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal | female | recessive

nob^KS49

viable | male

nob^KS49

Sterility

Allele

female sterile | recessive

nob^KS49

Other Phenotypes

Allele

abnormal behavior

nob^KS49

abnormal behavior | larval stage | recessive

nob^KS49

abnormal locomotor behavior

nob^KS49

abnormal locomotor behavior | recessive

nob^KS49

abnormal memory

nob^KS49

abnormal neurophysiology | adult stage

nob^KS49

abnormal pain response | adult stage

nob^KS49

short lived

nob^KS49

uncoordinated | recessive

nob^KS49

Phenotype manifest in

Allele

fan-shaped body

nob^KS49

protocerebral bridge

nob^KS49

protocerebral bridge glomerulus

nob^KS49

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:nob. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0002946

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-12

Cytogenetic map

4F7-4F11

Sequence location

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

4F7-4F11

Left limit from non-inclusion within Df(1)A113 (FBrf0056563) Right limit from inclusion within Df(1)HC244 (FBrf0056563)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

4F5-4F12

(Lindsley and Zimm, 1992)

Experimentally Determined Recombination Data

Location

1-12

(Varnam et al., 1996, Strauss et al., 1992)

Left of (cM)

(Strauss et al., 1992)

Right of (cM)

Notes

Stocks and Reagents

Stocks (0)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

nob is required for central complex formation.

(Fleischmann et al., 1995)

nob interacts with for.

(Sokolowski et al., 1995)

Mutations causing structural defects in the adult central complex also alter larval behavioural phenotypes.

(Varnam and Sokolowski, 1995)

nob interacts with for, nob causes sitting behaviour in for^R larvae.

(Burgess et al., 1994)

Mutants exhibit a disturbed protocerebral bridge. Results of antibody staining and behavioural assays suggest that the central complex may coordinate information processing in the two brain hemispheres.

(Bouhouche et al., 1993)

Behavioural and anatomical studies demonstrate that central brain lesions can be interpreted behaviourally.

(Heisenberg et al., 1985)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

nob

(Jordan et al., 2006, Xu et al., 2006)

Name Synonyms

no bridge

no protocerebral bridge

(Sun and Meinertzhagen, 1997)

no-bridge

(Buchanan et al., 2015, Xu et al., 2006)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 1 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0002946

References (37)

NA

Report Sections