Sgs-5
Please see the JBrowse view of Dmel\Sgs5 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
0.769 (sequence analysis)
There is only one protein coding transcript and one polypeptide associated with this gene
163 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sgs5 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Sgs5 in JBrowse3-61
3-59.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
Gene expression is unaffected in Eip74EFneo24 mutants but transcripts are barely detectable in Eip74EFDL-1 mutants.
Ecdysteroid-regulated gene.
Sgs5 encodes a salivary-gland glue protein. One of a group of seven genes encoding proteins that are components of the secretion produced by the larval salivary glands during the third instar for the purpose of attaching the larva to the substrate preparative to pupariation.
Sgs3, Sgs4 and Sgs5 transcript levels were very low in hemizygous brrbp-1 larvae and pupae.
Cessation of Sgs5 transcription and puff regression are ecdysterone-dependent.
Initiation of transcription of Sgs5, but not of intermolt-puff formation seems to depend on the presence of suitable levels of ecdysterone in early third instar larvae.
Synthesis of the glue proteins begins about 106 h after egg deposition and ceases abruptly within a few minutes after the glue is released 14 h later.
Initiation of transcription of Sgs5 is coincident with the formation of the intermolt puffs in early to mid third instar.
Source for merge of: Sgs5 BcDNA:LP02306
Source for merge of Sgs5 BcDNA:LP02306 was a shared cDNA ( date:030728 ).
Source for identity of: Sgs5 CG7596
