YP, vitellogenin, yolk protein
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 5.56
420 (aa); 46.1 (kD predicted)
Tyrosine sulfation occurs in the female only and plays an essential functional role.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Yp3 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Yp3 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
20-Hydroxyecdysone, but not juvenile hormone, regulation of yolk protein gene expression can be mapped to cis-acting DNA sequences upstream of, 3' to and within the Yp3 transcription unit. It is not clear whether regulation by 20-hydroxyecdysone is direct or indirect. Methoprene up-regulation is only observed when native yolk protein genes are assayed, suggesting that it may operate through influencing stability of the message.
Two independent cis-acting elements of 328bp and 419bp within a 747bp promoter region regulate the sex- and tissue-specific expression of Yp3.
Pattern of osmium zinc iodide staining in the cortical cytoplasm varies in relation to the number of yolk protein structural genes.
Structural gene for the yolk protein 3 found in recently-emerged female flies.
Evolutionary conservation of specificity of yolk protein uptake by the oocyte is studied throughout Diptera.
Female flies with varying numbers of Yp1, Yp2 and Yp3 genes have been generated. Each yolk protein gene makes an equivalent contribution to the fecundity and fertility of the female, and they do not individually provide unique functions to the embryo. The number of eggs laid by a female depends on the number of genes encoding yolk proteins present in the genome, and the probability of an egg producing an adult depends on the number of yolk protein genes present in the mother.
Postlethwait, July 1979.