FlyBase Gene Report: Dmel\Cp7Fa

General Information

Symbol

Dmel\Cp7Fa

Species

D. melanogaster

Name

Chorion protein a at 7F

Annotation Symbol

CG33962

Feature Type

protein_coding_gene

FlyBase ID

FBgn0014464

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Key Links

Genomic Location

Cytogenetic map

7F1-7F1

Sequence location

X:8,470,888..8,473,087 [+]

Recombination map

1-23

RefSeq locus

NC_004354 REGION:8470888..8473087

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse JBrowse2 (beta)

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural constituent of egg chorion

inferred by curator from GO:0007304

(Niepielko et al., 2014)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in chorion-containing eggshell formation

inferred from expression pattern

(Niepielko et al., 2014, Parks et al., 1986)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in chorion-containing eggshell formation

inferred from genomic context

(Parks et al., 1986)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in egg chorion

inferred by curator from GO:0007304

(Niepielko et al., 2014)

located_in egg chorion

inferred by curator from GO:0007304

(Parks et al., 1986)

inferred from genomic context

(Parks et al., 1986)

Gene Group / Complex (FlyBase)

CHORION PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group / Complex (FlyBase)

CHORION PROTEINS -: Chorion proteins (Cp) are encoded by gene clusters on the X and 3rd chromosome that undergo selective gene application in ovarian follicle cells during oogenesis. The Cp genes encode the major structural components of the eggshell chorion. (Adapted from FBrf0046094, FBrf0053248 and FBrf0227210.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cp7Fa for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A6F7S5S7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 6.27

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cp7Fa-RA

FBtr0100003

NM_001038748

1033

293

Cp7Fa-RB

FBtr0114578

NM_001382069

1183

343

Additional Transcript Data and Comments

Reported size (kB)

1.2 (northern blot)

(Parks et al., 1986)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cp7Fa-PA

FBpp0099518

32.3

293

5.29

FBpp0113070

38.2

343

7.40

ACL82910

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cp7Fa using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cp7Fa_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.36

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis stage S11 -- S12 & adult stage | female

floor cell

(Niepielko et al., 2014)

main body follicle cell | posterior

(Niepielko et al., 2014)

oogenesis stage S12 & adult stage | female

main body follicle cell

Comment: minus roof cell

(Niepielko et al., 2014)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis stage S12 -- S13

(Parks et al., 1986)

radioisotope in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage oogenesis stage S10B -- S13

follicle cell

(Parks and Spradling, 1987)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cp7Fa in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cp7Fa

View exonic expression by tissue for Dmel\Cp7Fa

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3885650/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014464

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014464

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014464

Flygut - An atlas of the Drosophila adult midgut

FBgn0014464

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cp7Fa

Transgenic constructs containing regulatory region of Cp7Fa

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 16 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Cp7Fa^GD8989

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Cp7Fa^GD8989

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cp7Fa^GD8989

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

Cp7Fa^GD8989

visible, with Scer\GAL4^pnr-MD237

Cp7Fa^GD8989

Phenotype manifest in

Allele

mesonotum, with Scer\GAL4^pnr-MD237

Cp7Fa^GD8989

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cp7Fa. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0014464

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-23

Cytogenetic map

7F1-7F1

Sequence location

X:8,470,888..8,473,087 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7F1-7F1

Limits computationally determined from genome sequence between P{EP}CG1632^EP1583 and P{EP}Moe^EP1652

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

7F-7F

(Spradling, 1995.8.11, Spradling et al., 1987)

Cp7Fa, Cp7Fb and Cp7Fc reside in the amplified chorion gene cluster that includes Cp36 and Cp38.

(Spradling, 1995.8.11)

Experimentally Determined Recombination Data

Location

1-23

(FlyBase, 2016)

1-23.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

53258

y¹ sc^* v¹ sev²¹; P{TRiP.GLC01818}attP2/TM3, Sb¹

15349R-1

v105029

v19431

w¹¹¹⁸; P{GD8989}v19431

Genomic Clones (5)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LP18486

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0014464

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

Dmel_dig_012624_0655_1698

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0014464

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Transcript maps within 10kb of Cp36.

(Spradling et al., 1987)

Relationship to Other Genes

Source for database merge of

Source for merge of: Cp7Fa CG15348 CG15349

(FlyBase Genome Annotators, 2005)

Additional comments

Annotations CG15348 and CG15349 merged as CG33962 (which corresponds to Cp7Fa) in release 4.3 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Nomenclature History

Source for database identify of

Source for identity of: Cp7Fa CG33962

(FlyBase Genome Annotators, 2005)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

(Spradling, 1995.8.11, Orr-Weaver, 1991, Spradling et al., 1987, Parks et al., 1986)

CG15348

CG15349

CG33962

(Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Fakhouri et al., 2006, FlyBase Genome Annotators, 2005)

Cp7Fa

(Tu et al., 2023, Hua and Orr-Weaver, 2017, Alexander et al., 2016, Hsu et al., 2015, Vartiainen et al., 2014, Peters et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Avet-Rochex et al., 2010, Turner et al., 2008, Fakhouri et al., 2006, Parks and Spradling, 1987)

Cp7fa

(Manica-Cattani et al., 2025)

Name Synonyms

Chorion protein a at 7F

(Spradling, 1995.8.11)

Secondary FlyBase IDs

FBgn0030042
FBgn0030043
FBgn0053962
FBtr0071199
FBpp0071146
FBtr0071200
FBpp0071147

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 29 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3885650

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

BT021351

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A6F7S5S7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A6F7S5S7

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3885650/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014464

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014464

FlyMine - An integrated database for Drosophila genomics

FBgn0014464

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33962

MARRVEL_MODEL - MARRVEL (model organism gene)

3885650

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0014464

DroID - A comprehensive database of gene and protein interactions.

FBgn0014464

DRSC - Results frm RNAi screens

FBgn0014464

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cp7Fa_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014464

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

DMEL:FBGN0014464

Flygut - An atlas of the Drosophila adult midgut

FBgn0014464

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014927

References (37)

The following external sites may use different assemblies or annotations than FlyBase.

-0.36

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