FlyBase Gene Report: Dmel\Acp29AB

General Information

Symbol

Dmel\Acp29AB

Species

D. melanogaster

Name

Accessory gland protein 29AB

Annotation Symbol

CG17797

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015583

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Accessory gland protein 29AB (Acp29AB) encodes a predicted C-type lectin that is produced by the male accessory glands and transferred to females during mating. After transfer to mated females, the Acp29AB product is detected in sperm storage organs and in the hemolymph. It plays a role in retention of sperm in storage and sperm competition. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Accessory gland-specific peptide 29AB, Acp29B

Key Links

Genomic Location

Cytogenetic map

29C1-29C1

Sequence location

2L:8,392,456..8,393,222 [-]

Recombination map

2-32

RefSeq locus

NT_033779 REGION:8392456..8393222

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables carbohydrate binding

inferred from sequence or structural similarity

(Mueller et al., 2004)

inferred from sequence or structural similarity with FLYBASE:Lectin-galC1; FB:FBgn0016675

(Tanji et al., 2006)

enables galactose binding

inferred from sequence or structural similarity

(Theopold et al., 1999)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in insemination

inferred from high throughput expression pattern

(Findlay et al., 2008)

involved_in mating

inferred from high throughput expression pattern

(Mueller et al., 2005)

involved_in sperm competition

inferred from mutant phenotype

(Wong et al., 2008)

involved_in sperm storage

inferred from mutant phenotype

(Wong et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in sperm competition

traceable author statement

(Chapman, 2001)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from high throughput direct assay

(Findlay et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from sequence model

(Mueller et al., 2005)

Gene Group (FlyBase)

C-TYPE LECTIN-LIKE

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

C-TYPE LECTIN-LIKE -: C-type lectins are Ca²⁺-dependent carbohydrate-binding proteins. They possess a C-type lectin fold, that is also present in proteins that do not bind carbohydrates. (Adapted from PMID:20301263.)

Protein Function (UniProtKB)

Responsible for physiological and behavioral changes in mated female flies.

(UniProt, O46197)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Acp29AB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O46197)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Acp29AB-RA

FBtr0079716

NM_078788

767

234

Additional Transcript Data and Comments

Reported size (kB)

0.95 (northern blot)

(Wolfner et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Acp29AB-PA

FBpp0079321

27.2

234

7.96

O46197

NP_523512

AAF52665

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

234 (aa)

(Wolfner et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

O46197

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Acp29AB using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Acp29AB_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.05

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

male accessory gland main cell

(Wolfner et al., 1997)

male accessory gland

(Wolfner et al., 1997)

Additional Descriptive Data

Expressed at high levels in male accessory gland main cells; not clear if transcript is expressed in secondary cells.

(Wolfner et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

male accessory gland

(Wong et al., 2008)

adult stage | female

spermatheca

Comment: in mated female, transferred from male

(Wong et al., 2008)

hemolymph

Comment: in mated female, transferred from male

(Wong et al., 2008)

Additional Descriptive Data

Acp29AB is absent from the reproductive tracts of virgin females and females 5 min ASM (after the start of mating), but is transferred to the female reproductive tract by 7 min ASM. Acp29AB localizes to the spermathecum 1 hour after mating and is also detectable in the hemolymph of the mated female.

(Wong et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular region

inferred from high throughput direct assay

(Findlay et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Acp29AB in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Acp29AB

View exonic expression by tissue for Dmel\Acp29AB

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015583

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34162/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015583

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015583

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015583

Flygut - An atlas of the Drosophila adult midgut

FBgn0015583

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 43 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Acp29AB

Transgenic constructs containing regulatory region of Acp29AB

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Acp29AB^GD5362

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Acp29AB^GD5362

viable, with Scer\GAL4^hs.PB

Acp29AB^UAS.cLa

viable, with Scer\GAL4^Mef2.PR

Acp29AB^GD5362

viable, with Scer\GAL4^αTub84B.PL

Acp29AB^UAS.cLa

Sterility

Allele

fertile (with Df(2L)ED611)

Acp29AB^W1

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

Acp29AB^GD5362

visible, with Scer\GAL4^pnr-MD237

Acp29AB^GD5362

Phenotype manifest in

Allele

trichogen cell, with Scer\GAL4^pnr-MD237

Acp29AB^GD5362

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (55)

Hsap\CLEC1B

3 of 14

Yes

Hsap\COLEC10

3 of 14

Yes

Hsap\CD207

2 of 14

Hsap\CLEC1A

2 of 14

Yes

Hsap\CLEC2L

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\CLEC12B

2 of 14

Yes

Hsap\CLEC17A

2 of 14

Hsap\COLEC11

2 of 14

Hsap\KLRK1

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CLEC2B

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\COLEC12

1 of 14

Yes

Hsap\FCER2

1 of 14

Hsap\KLRC1

1 of 14

Yes

Hsap\KLRC2

1 of 14

Yes

Hsap\KLRC3

1 of 14

Yes

Hsap\KLRC4-KLRK1

1 of 14

Yes

Hsap\KLRD1

1 of 14

Yes

Hsap\KLRF2

1 of 14

Yes

Hsap\KLRG1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (74)

Rnor\Clec1b

4 of 14

Yes

Rnor\Clec1a

3 of 14

Yes

Rnor\Clec7a

3 of 14

Yes

Rnor\Clec9a

3 of 14

Yes

Rnor\Clec12b

3 of 14

Yes

Rnor\Colec10

3 of 14

Rnor\Klrh1

3 of 14

Yes

Rnor\Klrk1

3 of 14

Yes

Rnor\LOC497796

3 of 14

Yes

Rnor\Cd207

2 of 14

Rnor\Cd209e

2 of 14

Rnor\Clec2l

2 of 14

Yes

Rnor\Clec4f

2 of 14

Rnor\Clec4g

2 of 14

Yes

Rnor\Colec11

2 of 14

Rnor\Klra1

2 of 14

Yes

Rnor\Klra2

2 of 14

Yes

Rnor\Klra22

2 of 14

Yes

Rnor\Klrd1

2 of 14

Yes

Rnor\Klrg2

2 of 14

Yes

Rnor\Klri1

2 of 14

Yes

Rnor\Klri2

2 of 14

Yes

Rnor\LOC502907

2 of 14

Yes

Rnor\LOC690020

2 of 14

Yes

Rnor\Ly49i7

2 of 14

Yes

Rnor\Ly49s4

2 of 14

Yes

Rnor\Ly49s5

2 of 14

Yes

Rnor\Ly49s6

2 of 14

Yes

Rnor\Ly49si1

2 of 14

Yes

Rnor\Ly49si2

2 of 14

Yes

Rnor\Ly49si3

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Clec2e

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Colec12

1 of 14

Rnor\Fcer2

1 of 14

Rnor\Klra5

1 of 14

Yes

Rnor\Klrb1b

1 of 14

Rnor\Klrc1

1 of 14

Yes

Rnor\Klrc2

1 of 14

Yes

Rnor\Klrc3

1 of 14

Yes

Rnor\Klre1

1 of 14

Rnor\LOC502908

1 of 14

Yes

Rnor\LOC689757

1 of 14

Yes

Rnor\LOC690097

1 of 14

Rnor\Ly49i2

1 of 14

Yes

Rnor\Ly49i4

1 of 14

Yes

Rnor\Ly49s7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Pla2r1

1 of 14

Rnor\Sell

1 of 14

Mus musculus (laboratory mouse) (70)

Mmus\Clec1b

3 of 14

Yes

Mmus\Colec10

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Clec2l

2 of 14

Yes

Mmus\Clec4f

2 of 14

Mmus\Clec7a

2 of 14

Yes

Mmus\Clec9a

2 of 14

Yes

Mmus\Colec11

2 of 14

Mmus\Klra1

2 of 14

Yes

Mmus\Klra4

2 of 14

Yes

Mmus\Klra9

2 of 14

Yes

Mmus\Klrg2

2 of 14

Yes

Mmus\Klrh1

2 of 14

Yes

Mmus\Klri1

2 of 14

Yes

Mmus\Klri2

2 of 14

Yes

Mmus\Klrk1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Clec2g

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Clec12b

1 of 14

Yes

Mmus\Colec12

1 of 14

Mmus\Fcer2a

1 of 14

Mmus\Klra2

1 of 14

Yes

Mmus\Klra3

1 of 14

Mmus\Klra5

1 of 14

Mmus\Klra6

1 of 14

Yes

Mmus\Klra7

1 of 14

Yes

Mmus\Klra8

1 of 14

Yes

Mmus\Klra10

1 of 14

Mmus\Klra17

1 of 14

Yes

Mmus\Klrb1a

1 of 14

Yes

Mmus\Klrb1b

1 of 14

Yes

Mmus\Klrc1

1 of 14

Yes

Mmus\Klrc2

1 of 14

Yes

Mmus\Klrc3

1 of 14

Yes

Mmus\Klrd1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Reg2

1 of 14

Mmus\Sell

1 of 14

Xenopus tropicalis (Western clawed frog) (28)

Xtro\cd302

2 of 13

Yes

Xtro\clec4m

2 of 13

Yes

Xtro\colec10

2 of 13

Yes

Xtro\LOC100496055

2 of 13

Yes

Xtro\LOC101731226

2 of 13

Yes

Xtro\pla2r1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\layn

1 of 13

Yes

Xtro\LOC100489411

1 of 13

Xtro\LOC100494969

1 of 13

Xtro\LOC101731294

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\mrc1

1 of 13

Xtro\mrc2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (106)

Drer\cd209

3 of 14

Yes

Drer\colec11

3 of 14

Yes

Drer\hbl1

3 of 14

Yes

Drer\hbl2

3 of 14

Yes

Drer\hbl4

3 of 14

Yes

Drer\LOC101884526

3 of 14

Yes

Drer\LOC101885237

3 of 14

Yes

Drer\mbl2

3 of 14

Yes

Drer\si:ch73-335d12.2

3 of 14

Yes

Drer\si:ch211-63p21.3

3 of 14

Yes

Drer\si:ch211-63p21.4

3 of 14

Yes

Drer\si:ch211-225k7.2

3 of 14

Yes

Drer\si:ch211-225k7.3

3 of 14

Yes

Drer\si:ch211-225k7.4

3 of 14

Yes

Drer\si:ch211-225k7.6

3 of 14

Yes

Drer\si:ch211-272h9.3

3 of 14

Yes

Drer\si:ch211-282j17.3

3 of 14

Yes

Drer\si:ch211-282j17.5

3 of 14

Yes

Drer\si:ch211-282j17.11

3 of 14

Yes

Drer\si:dkey-28d5.10

3 of 14

Yes

Drer\si:dkey-28d5.13

3 of 14

Yes

Drer\si:dkey-83f18.2

3 of 14

Yes

Drer\si:dkey-83f18.3

3 of 14

Yes

Drer\si:dkey-83f18.4

3 of 14

Yes

Drer\si:dkey-83f18.5

3 of 14

Yes

Drer\si:dkey-83f18.6

3 of 14

Yes

Drer\si:dkey-83f18.7

3 of 14

Yes

Drer\si:dkey-83f18.9

3 of 14

Yes

Drer\si:dkey-83f18.11

3 of 14

Yes

Drer\si:dkey-88n24.3

3 of 14

Yes

Drer\si:dkey-88n24.6

3 of 14

Yes

Drer\si:dkey-88n24.7

3 of 14

Yes

Drer\si:dkeyp-94g1.1

3 of 14

Yes

Drer\zgc:162060

3 of 14

Yes

Drer\colec10

2 of 14

Yes

Drer\dcsignlg

2 of 14

Drer\lectin

2 of 14

Drer\LOC100536834

2 of 14

Yes

Drer\LOC101884413

2 of 14

Drer\si:cabz01083838.1

2 of 14

Yes

Drer\si:ch211-125e6.5

2 of 14

Drer\si:ch211-125e6.12

2 of 14

Drer\si:ch211-125e6.13

2 of 14

Drer\si:ch211-125e6.14

2 of 14

Drer\si:ch211-225k7.5

2 of 14

Yes

Drer\si:ch211-282j17.2

2 of 14

Drer\si:ch211-282j17.8

2 of 14

Yes

Drer\si:ch211-282j17.10

2 of 14

Yes

Drer\si:dkey-28d5.3

2 of 14

Yes

Drer\si:dkey-28d5.4

2 of 14

Yes

Drer\si:dkey-28d5.8

2 of 14

Yes

Drer\si:dkey-28d5.12

2 of 14

Yes

Drer\si:dkey-28d5.14

2 of 14

Yes

Drer\si:dkey-81n2.1

2 of 14

Drer\si:dkey-81n2.2

2 of 14

Yes

Drer\si:dkey-83f18.8

2 of 14

Drer\si:dkey-83f18.10

2 of 14

Yes

Drer\si:dkey-88n24.8

2 of 14

Yes

Drer\si:dkey-88n24.10

2 of 14

Yes

Drer\si:dkey-187i8.2

2 of 14

Drer\si:dkey-192d15.3

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\clec11a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC101882781

1 of 14

Drer\LOC101885900

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\selp

1 of 14

Drer\si:busm1-169i8.11

1 of 14

Drer\si:ch73-111e15.1

1 of 14

Drer\si:ch73-122g19.1

1 of 14

Drer\si:ch211-125e6.11

1 of 14

Drer\si:ch211-170d8.8

1 of 14

Drer\si:ch211-193e13.5

1 of 14

Drer\si:ch211-214k5.3

1 of 14

Drer\si:dkey-9i23.5

1 of 14

Drer\si:dkey-11o15.4

1 of 14

Yes

Drer\si:dkey-11o15.5

1 of 14

Drer\si:dkey-61f9.1

1 of 14

Drer\si:dkey-187j14.6

1 of 14

Yes

Drer\si:dkeyp-75b4.10

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (39)

Cele\clec-149

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\clec-89

1 of 14

Cele\clec-93

1 of 14

Yes

Cele\clec-94

1 of 14

Yes

Cele\clec-99

1 of 14

Cele\clec-103

1 of 14

Yes

Cele\clec-104

1 of 14

Yes

Cele\clec-106

1 of 14

Yes

Cele\clec-118

1 of 14

Cele\clec-126

1 of 14

Yes

Cele\clec-127

1 of 14

Cele\clec-129

1 of 14

Cele\clec-130

1 of 14

Yes

Cele\clec-132

1 of 14

Yes

Cele\clec-133

1 of 14

Cele\clec-144

1 of 14

Cele\clec-145

1 of 14

Yes

Cele\clec-163

1 of 14

Yes

Cele\clec-164

1 of 14

Yes

Cele\clec-169

1 of 14

Yes

Cele\clec-172

1 of 14

Yes

Cele\clec-181

1 of 14

Cele\clec-186

1 of 14

Yes

Cele\clec-207

1 of 14

Yes

Cele\clec-208

1 of 14

Cele\clec-228

1 of 14

Yes

Cele\clec-229

1 of 14

Yes

Cele\clec-230

1 of 14

Yes

Cele\clec-231

1 of 14

Yes

Cele\clec-241

1 of 14

Yes

Cele\clec-243

1 of 14

Yes

Cele\R02F11.12

1 of 14

Yes

Cele\Y54G2A.7

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (23)

Agam\AgaP_AGAP002911

3 of 12

Yes

Agam\CTLGA4

3 of 12

Yes

Agam\AgaP_AGAP002910

2 of 12

Yes

Agam\AgaP_AGAP007409

2 of 12

Agam\AgaP_AGAP010707

2 of 12

Yes

Agam\CTL2

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Acp29AB. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (31)

9 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

5 of 13

5 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

tfc

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

COLEC10; collectin subfamily member 10

model of 3MC syndrome 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CLEC1B; C-type lectin domain family 1 member B

3 of 14

606783

COLEC10; collectin subfamily member 10

3 of 14

607620

3MC SYNDROME 3; 3MC3

3MC syndrome 3

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60286

DroID - A comprehensive database of gene and protein interactions.

FBgn0015583

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-32

Cytogenetic map

29C1-29C1

Sequence location

2L:8,392,456..8,393,222 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

29C1-29C1

Limits computationally determined from genome sequence between P{lacW}l(2)k12914^k12914&P{lacW}Akap200^k07118a and P{lacW}l(2)k03706^k03706&P{lacW}Acer^k07704

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

29C1-29C5

(Celniker, 1998.3.17)

29A-29B

(Aguade, 1999.2.19)

29A-29B

(determined by in situ hybridisation)

(Wolfner et al., 1997)

29B-29B

(determined by in situ hybridisation)

(Clark et al., 1995)

Experimentally Determined Recombination Data

Location

2-32

(FlyBase, 2016)

2-27.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

77372

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06058}attP40

NIG-Fly

M2L-2213

y¹ w¹¹¹⁸; Acp29AB^SK3 P{neoFRT}40A/CyO-Tb

2LG-1762

y² VhaAC39-1^cho-1 v¹; P{U6-Acp29AB.NIG.sgRNA}attP40/CyO

VDRC

v100995

P{KK106504}VIE-260B

v41211

w¹¹¹⁸; P{GD5362}v41211/TM3

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP02113

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015583

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015583

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Wong et al., 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Acp29AB is required for the normal maintenance of sperm in storage.

(Wong et al., 2008)

Isolated in a screen for seminal fluid proteins.

(Mueller et al., 2004)

Gene is identified in a differential cDNA hybridisation screen.

(Wolfner et al., 1997)

If females remate frequently relative to the duration of sperm storage and rate of sperm use, sperm displacement may be an important component of male reproductive success. Significant association has been found between Acp29AB mutant male sperm and the ability to resist displacement by subsequent sperm. There is no correlation between the ability to displace resident sperm and the ability to resist being displaced by subsequent sperm, this lack of correlation suggests that different mechanisms mediate that the two components of sperm displacement.

(Clark et al., 1995)

May promote replacement of sperm already stored by a female.

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Acp29AB CG17797

(Theopold, 2000.7.21)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

AC 004423B

(Theopold et al., 1999)

AC004423b

(Theopold, 2000.7.21)

Acp29

(Zurovcova et al., 2006)

Acp29AB-II

(Wijffels et al., 2001)

Acp29B

(Clark et al., 1995)

CG17797

(National Institute of Genetics Fly Stocks, 2022-, Patlar and Civetta, 2022, Lu et al., 2020, Hosono et al., 2015, Chen et al., 2012, Zhang et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Mueller et al., 2005)

Name Synonyms

Accessory gland protein 29AB

(Wolfner et al., 1997)

Accessory gland-specific peptide 29AB

(Takemori and Yamamoto, 2009)

accessory gland protein

(Theopold, 2000.7.21)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 210 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34162

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O46197

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

O46197

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O46197

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015583

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34162/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015583

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015583

FlyMine - An integrated database for Drosophila genomics

FBgn0015583

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17797

MARRVEL_MODEL - MARRVEL (model organism gene)

34162

Linkouts

BioGRID - A database of protein and genetic interactions.

60286

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015583

DroID - A comprehensive database of gene and protein interactions.

FBgn0015583

DRSC - Results frm RNAi screens

FBgn0015583

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Acp29AB_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015583

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015583

Flygut - An atlas of the Drosophila adult midgut

FBgn0015583

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (84)

The following external sites may use different assemblies or annotations than FlyBase.

-0.05

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