Please see the JBrowse view of Dmel\NijB for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Composed of 4 alpha helices: 2 hydrophobic transmembrane regions (alpha3 and alpha4) and 2 alpha helices (alpha1 and alpha2) (By similarity). Alpha1 and alpha2 feature one hydrophobic side and a hydrophilic side (By similarity). In normal conditions, NijB is inactivated and alpha1 and alpha2 helices are not inserted into the membrane (By similarity). Following NijB activation, alpha1 and alpha2 helices insert into the membrane and drive NijB oligomerization via interactions between alpha3 and alpha4 and the hydrophobic face of alpha1 from an adjacent subunit (By similarity). Such structures disrupt membrane integrity and form a lesion through the introduction of the hydrophilic faces of alpha1 and alpha2 into the hydrophobic membrane (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NijB using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\NijB in JBrowse3-45
3-42.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: NijB CG11637
