FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\jagn
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General Information
Symbol
Dmel\jagn
Species
D. melanogaster
Name
jagunal
Annotation Symbol
CG10978
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037374
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
jagunal (jagn) encodes a conserved protein that is located in the endoplasmic reticulum membrane. It contributes to oocyte growth by organizing the endoplasmic reticulum. It is also involved in bristle growth. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
83C3-83C3
Sequence location
Recombination map
3-47.5
RefSeq locus
NT_033777 REGION:5779315..5781308
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in chaeta development
inferred from mutant phenotype
(Lee and Cooley, 2007)
involved_in chaeta morphogenesis
inferred from mutant phenotype
(Lee and Cooley, 2007)
involved_in endoplasmic reticulum organization
inferred from mutant phenotype
(Lee and Cooley, 2007)
involved_in establishment of ER localization
inferred from mutant phenotype
(Lee and Cooley, 2007)
involved_in exocytosis
inferred from mutant phenotype
(Lee and Cooley, 2007)
involved_in oocyte growth
inferred from mutant phenotype
(Lee and Cooley, 2007)
involved_in vitellogenesis
inferred from mutant phenotype
(Lee and Cooley, 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum organization
inferred from electronic annotation with InterPro:IPR009787
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN001076220
(GO Reference Genome Project, 2011-)
involved_in vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN001076220
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endoplasmic reticulum membrane
inferred from direct assay
(Lee and Cooley, 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in endoplasmic reticulum membrane
inferred from biological aspect of ancestor with PANTHER:PTN001076220
(GO Reference Genome Project, 2011-)
located_in endoplasmic reticulum membrane
inferred from electronic annotation with InterPro:IPR009787
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the jagunal family. (Q7K1V5)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
jagunal (jagn) encodes a conserved protein that is located in the endoplasmic reticulum membrane. It contributes to oocyte growth by organizing the endoplasmic reticulum. It is also involved in bristle growth. [Date last reviewed: 2019-03-07]
Protein Function (UniProtKB)
Required for endoplasmic reticulum organization and proper vesicular traffic during vitellogenesis. Required for oocyte and bristle growth.
(UniProt, Q7K1V5)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\jagn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7K1V5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
jagn-RA
FBtr0078625
NM_141328
1104
197
jagn-RB
FBtr0078624
NM_169103
1649
197
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
jagn-PA
FBpp0078274
23.0
197
6.77
Q7K1V5
NP_649585
AAN14321
jagn-PB
FBpp0078273
23.0
197
6.77
Q7K1V5
NP_731002
AAF51956
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

197 aa isoforms: jagn-PA, jagn-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jagn using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.88

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endoplasmic reticulum membrane
inferred from direct assay
(Lee and Cooley, 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\jagn in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of jagn
Transgenic constructs containing regulatory region of jagn
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | first instar larval stage | recessive
lethal | recessive
lethal | recessive | second instar larval stage
partially lethal - majority die | recessive
Phenotype manifest in
Allele
endoplasmic reticulum & oocyte | germ-line clone
macrochaeta | somatic clone
microchaeta | somatic clone
microvillus & oocyte | germ-line clone
nurse cell | germline clone
oocyte | germline clone
wing margin bristle | somatic clone
yolk granule & oocyte | germ-line clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\JAGN1
12 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Jagn1
13 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Jagn1
12 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\jagn1
10 of 13
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\jagn1a
13 of 14
Yes
Yes
Drer\jagn1b
13 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\K05C4.2
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP003240
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT5G51510
4 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:jagn. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    JAGN1; jagunal vesicle mediated transporter 1
    model of  severe congenital neutropenia 6
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    JAGN1; jagunal vesicle mediated transporter 1
    12 of 14
    616012
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    jagn - ATPsynB
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - ATPsynCF6
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - ATPsynO
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - CG2070
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - CG3164
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - CG31729
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - CG7601
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - CG8195
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Ipo9
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Karyβ3
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Kdsr
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Kr-h2
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - MRP
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Mec2
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Ost48
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Ostc
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - OstΔ
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - PMCA
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Past1
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Rab1
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Rab7
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Rdh1
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Rer1
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - SERCA
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Scamp
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Sec61α
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Surf4
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - Tecr
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - ZnT63C
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - bbc
    experimental knowledge based
    (Guruharsha et al., 2011)
    jagn - sun
    experimental knowledge based
    (Guruharsha et al., 2011)
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-47.5
    Cytogenetic map
    83C3-83C3
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    83C3-83C3
    Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    83C-83C
    (Lee and Cooley, 2004)
    Experimentally Determined Recombination Data
    Location

    3-47.5

    (FlyBase, 2016)

    3-44.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (4)
    Genomic Clones (16)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (65)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          jagn is required for reorganising the endoplasmic reticulum (ER) through ER clustering in the oocyte during vitellogenesis. jagn is also required for bristle growth.

          (Lee and Cooley, 2007)

          Identification: In a study of lethal mutations that in germ line clones cause a defect in nurse cell cytoplasm transport during oogenesis.

          (Lee and Cooley, 2004)

          Oocyte integrity during rapid cytoplasm transport requires jagn.

          (Lee and Cooley, 2004)

          jagn causes a defect in the oocyte structure after stage 10. The anterior region of mutant oocytes becomes detached from adjacent nurse cells and follicle cells. The phenotype begins to appear during stage 10 and becomes severe as the oocyte begins to grow rapidly during stage 11, resulting in small eggs. In jagn mutant oocytes, the movement of anterior cytoplasm is defective in stage 10A and jagn ooplasm fails to shift direction to form a whirlpool during stage 10B. exu-containing particle movement is defective in the jagn germline clones. Both macrochaetes and microchaetes formed in jagn clones are short and thin. The jagn macrochaetes are structurally unstable and easily detached. Clones of jagn mutation also cause defects in eye development and follicle cell morphogenesis.

          (Lee and Cooley, 2004)
          Relationship to Other Genes
          Source for database merge of
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: jagn CG10978

          (Lee, 2004.2.26)
          Nomenclature comments
          Etymology

          The gene is named "jagunal", which means "small egg" in Korean, as mutations in the gene severely affect oocyte growth.

          (Lee and Cooley, 2007)

          "jagunal" means small egg in Korean.

          (Lee, 2004.2.26)
          Synonyms and Secondary IDs (4)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 34 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (36)