FB2020_06, released Dec 22, 2020

Gene: Dmel\CG46301

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General Information
Symbol
Dmel\CG46301
Species
D. melanogaster
Name
Annotation Symbol
CG46301
Feature Type
protein_coding_gene
FlyBase ID
FBgn0283651
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

BG:DS01759.1 , BG:DS01523.1

Key Links
Genomic Location
Cytogenetic map
34F4-34F4
Sequence location
2L:14,104,090..14,160,587 [+]
Recombination map

2-50

RefSeq locus
NT_033779 REGION:14104090..14160587
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (1 term)
Molecular Function (0 terms)
There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2017-08-16 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
There is no information supporting a Biological Process term for this gene. (Based on a review of available data on: 2017-08-16 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleoplasm
inferred from sequence or structural similarity with HGNC:16106
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\CG46301 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.44

Gene model includes transcripts encoding non-overlapping portions of the full CDS.

Gene model reviewed during 6.10

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG46301-RC
FBtr0445731
NM_001347776
2385
623
CG46301-RD
FBtr0445729
NM_135859
4048
636
CG46301-RE
FBtr0445730
NM_001347777
5632
1237
CG46301-RF
FBtr0445732
NM_001347778
2458
667
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG46301-PC
FBpp0401606
67.8
623
9.80
NP_001334738
API64989
CG46301-PD
FBpp0401604
64.0
636
6.19
NP_609703
API64987
CG46301-PE
FBpp0401605
129.2
1237
8.24
NP_001334737
API64988
CG46301-PF
FBpp0401607
72.7
667
9.43
NP_001334739
API64990
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG46301 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG46301 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG46301
Transgenic constructs containing regulatory region of CG46301
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NOL4
8 of 15
Yes
Yes
Hsap\NOL4L
7 of 15
No
Yes
Hsap\KRT9
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nol4l
7 of 15
Yes
Yes
Mmus\Nol4
7 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Nol4
6 of 13
Yes
Yes
Rnor\Nol4l
5 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\nol4
4 of 12
Yes
Yes
Xtro\nol4l
3 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\nol4la
7 of 15
Yes
Yes
Drer\nol4lb
7 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907B5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000867
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000869
Drosophila simulans
Dsim\GD23954
Drosophila simulans
Dsim\GD23955
Drosophila sechellia
Dsec\GM15483
Drosophila sechellia
Dsec\GM15494
Drosophila erecta
Dere\GG23912
Drosophila erecta
Dere\GG23913
Drosophila yakuba
Dyak\GE19024
Drosophila yakuba
Dyak\GE19026
Drosophila ananassae
Dana\GF14281
Drosophila ananassae
Dana\GF14280
Drosophila pseudoobscura pseudoobscura
Dpse\GA14191
Drosophila pseudoobscura pseudoobscura
Dpse\GA14469
Drosophila persimilis
Dper\GL21260
Drosophila persimilis
Dper\GL21261
Drosophila willistoni
Dwil\GK15032
Drosophila willistoni
Dwil\GK15033
Drosophila virilis
Dvir\GJ18173
Drosophila virilis
Dvir\GJ18174
Drosophila mojavensis
Dmoj\GI12769
Drosophila mojavensis
Dmoj\GI12780
Drosophila grimshawi
Dgri\GH11137
Drosophila grimshawi
Dgri\GH11138
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150578 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021929
Musca domestica
House fly
Mdoa\17016935
Glossina morsitans
Tsetse fly
Gmor\GMOY002313
Glossina morsitans
Tsetse fly
Gmor\GMOY005774
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02575
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01765
Mayetiola destructor
Hessian fly
Mdes\Mdes004979
Mayetiola destructor
Hessian fly
Mdes\Mdes004978
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014981
Anopheles darlingi
American malaria mosquito
Adar\ADAC002970
Anopheles gambiae
Malaria mosquito
Agam\AGAP008189
Anopheles gambiae
Malaria mosquito
Agam\AGAP008187
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000481
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000480
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05KZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004393
Bombyx mori
Silkmoth
Bmor\BGIBMGA004392
Danaus plexippus
Monarch butterfly
Dple\DPOGS213419-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213416-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016808
Heliconius melpomene
Postman butterfly
Hmel\HMEL016809
Apis florea
Little honeybee
Aflo\2147586067
Apis florea
Little honeybee
Aflo\3757092628
Apis florea
Little honeybee
Aflo\2147484049
Apis mellifera
Western honey bee
Amel\GB40522
Apis mellifera
Western honey bee
Amel\GB40521
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23720
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21652
Bombus terrestris
Buff-tailed bumblebee
Bter\15207195
Bombus terrestris
Buff-tailed bumblebee
Bter\15207193
Linepithema humile
Argentine ant
Lhum\LH24173
Linepithema humile
Argentine ant
Lhum\LH24181
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001518
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001510
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003762
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003765
Tribolium castaneum
Red flour beetle
Tcas\TC031212
Pediculus humanus
Human body louse
Phum\PHUM456130
Pediculus humanus
Human body louse
Phum\PHUM456120
Pediculus humanus
Human body louse
Phum\PHUM456110
Rhodnius prolixus
Kissing bug
Rpro\RPRC001425
Rhodnius prolixus
Kissing bug
Rpro\RPRC001426
Cimex lectularius
Bed bug
Clec\CLEC002101
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008172
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06554
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05H5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009460
Ixodes scapularis
Black-legged tick
Isca\ISCW010756
Ixodes scapularis
Black-legged tick
Isca\ISCW010757
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78073.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78074.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g04220
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_100633
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03G2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_013567gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_014680gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-C20orf112
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028251
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027669
Gallus gallus
Domestic chicken
Ggal\NOL4
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NOL4; nucleolar protein 4
    8 of 15
    603577
        NOL4L; nucleolar protein 4 like
        7 of 15
        618893
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map

            2-50

            Cytogenetic map
            34F4-34F4
            Sequence location
            2L:14,104,090..14,160,587 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            34F4-34F4
            Limits computationally determined from genome sequence between P{lacW}l(2)34Fak00811&P{PZ}wb09437 and P{EP}elBEP2039&P{PZ}osprJ571
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            2-50

            (FlyBase, 2016)

            2-45.8

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (6)
            Genomic Clones (49)
            cDNA Clones (22)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of

            Source for merge of:CG16879 CG17341

            (FlyBase Genome Annotators, 2016)
            Additional comments

            Annotations CG16879 and CG17341 merged as CG46301 in release 6.10 of the genome annotation; supported by RNA-Seq junction data and alignment to similar proteins in other insect species.

            (FlyBase Genome Annotators, 2016)
            Other Comments
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 32 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            Linkouts
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Synonyms and Secondary IDs (6)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (34)