In genome-wide association studies (GWAS), the human gene IDE has been associated with type 2 diabetes and waist-to-hip ratio. Deficiencies in IDE protein function are associated with Alzheimer disease and type 2 diabetes mellitus, but specific mutations in the IDE gene have not been shown to be causative for either disease. IDE encodes a zinc metallopeptidase that degrades intracellular insulin, as well as a diverse collection of other peptides. There is a single orthologous gene in Drosophila, Dmel\Ide, for which an amorphic allele created by targeted recombination, RNAi-targeting constructs, and alleles caused by insertional mutagenesis have been generated.
Several different UAS constructs of the wild-type human Hsap\IDE gene have been introduced into flies and have been characterized in terms of impact on the fly insulin signaling pathway.
Results in flies suggest a conserved role for IDE in sugar metabolism. Animals homozygous for an amorphic mutation of Dmel\Ide are viable and fertile, however, they display a higher level of the sugar trehalose in their hemolymph. Circulating levels of trehalose drop sharply after 24 hr starvation in wild type adult flies; in Ide mutant animals levels remain close to those observed before starvation. An increased developmental delay is observed when larvae are raised on a high-sucrose diet. A small number of physical and genetic interactions have been described for Dmel\Ide; see below and in the Ide gene report.
[updated Jan. 2020 by FlyBase; FBrf0222196]
IDE is associated with type 2 diabetes and waist-to-hip ratio in GWAS studies (see GWAS Catalog, below in 'External links').
Deficiencies in IDE protein function are associated with Alzheimer disease and type 2 diabetes mellitus, but mutations in the IDE gene have not been shown to be causative for these diseases. [Gene Cards, IDE; 2020.01.24]
IDE encodes a zinc metallopeptidase that degrades intracellular insulin, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. It may play a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia. [Gene Cards, IDE; 2020.01.24]
One to one: 1 human to 1 Drosophila.
High-scoring ortholog of human IDE (1 Drosophila to 1 human).
