FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
PGRP-LE, pirk
FlyBase ID
FBig0000053867
Interaction Network
Interactions Browser links
PGRP-LE network
pirk network
Reported Interactions
FBrf0205806-2.coIP.WB
Reference
Aggarwal et al., 2008
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
PGRP-LE 

PGRP-LE

bait

FLAG tag

PGRP-LE 
pirk 

Rdr

prey

T7 tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
PGRP-LE 
RHIM motif
necessary binding region
aa 98-113

coordinates relative to PGRP-LE-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2* or HEK cell line; bait produced from transfected construct; prey produced from transfected construct.

(Aggarwal et al., 2008)
FBrf0205806-6.coIP.A
Reference
Aggarwal et al., 2008
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
PGRP-LE 

PGRP-LE

bait

T7 tag, [35]S label

pirk 

Rdr

prey

FLAG tag, [35]S label

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced and labeled by in vitro translation; prey produced and labeled by in vitro translation.

(Aggarwal et al., 2008)

fected construct.

(Aggarwal et al., 2008)
FBrf0218395-8650.DPiM
Reference
Guruharsha et al., 2011
Description
physical association
Assay
Collection
DPiM-2
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
PGRP-LE 
unspecified role
PGRP-LE 
unspecified role
PGRP-LE 
unspecified role
pirk 
unspecified role
pirk 
unspecified role
pirk 
unspecified role
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

HGScore = 210.50562

External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)