FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
bowl, lin
FlyBase ID
FBig0000096043
Interaction Network
Interactions Browser links
bowl network
lin network
Reported Interactions
FBrf0183988-1.coIP.WB
Reference
Hatini et al., 2005
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
bowl 

Bowl

bait

FLAG tag

lin 

Lines

prey

Myc tag

lin 
lin 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
lin 
zinc finger domain
sufficient binding region
lin 
zinc finger domain
mutation disrupting interaction
aa 258

R258C

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Hatini et al., 2005)

Interacton inhibited by the addition of drm.

(Hatini et al., 2005)
FBrf0219018-1.coIP.WB
Reference
Del Signore et al., 2012
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
lin 

lin

bait

Myc tag

bowl 

bowl

prey

Flag tag

bowl 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
bowl 
N terminal zinc finger
mutation disrupting interaction
aa 258

R258C

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Del Signore et al., 2012)
FBrf0260300-2.coIP.WB
Reference
Wen et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2R+
Participants
Corresponds to
Reported as
Role
Note
lin 

Lin

bait

FLAG tag

lin 
bowl 

Bowl

prey

HA tag

bowl 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
lin 
missense mutant residue 139
mutation decreasing interaction
aa 139

K139R; coordinates relative to lin-PA

bowl 
interaction domain
sufficient binding region
aa 122-373

K139R; coordinates relative to bowl-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Co-expression of drm disrupts lin-bowl interaction.

(Wen et al., 2024)

Source was cell extract of S2R+ cell line; bait produced from transfected construct; prey produced from transfected construct.

(Wen et al., 2024)
FBrf0260300-3.coIP.WB
Reference
Wen et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2R+
Participants
Corresponds to
Reported as
Role
Note
bowl 

Bowl

bait

FLAG tag

lin 

Lin

prey

Myc tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2R+ cell line; bait produced from transfected construct; prey produced from transfected construct.

(Wen et al., 2024)
FBrf0260300-5.coIP.WB
Reference
Wen et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2R+
Participants
Corresponds to
Reported as
Role
Note
bowl 

Bowl

bait

HA tag

bowl 
lin 

Lin

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
bowl 
Zinc finger domain
sufficient binding region
aa 190-373

coordinates relative to bowl-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2R+ cell line; bait produced from transfected construct; prey produced from transfected construct.

(Wen et al., 2024)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)