FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
AGO1, Dcr-1
FlyBase ID
FBig0000098321
Interaction Network
Interactions Browser links
AGO1 network
Dcr-1 network
Reported Interactions
FBrf0179363-1.coIP.WB
Reference
Okamura et al., 2004
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
AGO1 

AGO1

bait

TAP tag

Dcr-1 

Dicer-1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Dcr-1 coimmunoprecipitates with AGO1 but not AGO2 in this assay.

(Okamura et al., 2004)

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Okamura et al., 2004)
FBrf0187593-2.coIP.WB
Reference
Jiang et al., 2005
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Dcr-1 

Dicer-1

bait
AGO1 

AGO1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

AGO1 coimmunoprecipitates with Dcr-1 but not Dcr-2.

(Jiang et al., 2005)

Source was cell extract of S2 cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Jiang et al., 2005)
FBrf0188216-7.coIP.WB
Reference
Saito et al., 2005
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
AGO1 

AGO1

bait

TAP tag

Dcr-1 

Dcr-1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Dcr-1 coimmunoprecipitates with AGO1 but not AGO2.

(Saito et al., 2005)

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Saito et al., 2005)
FBrf0206327-2.coIP.WB
Reference
Xu et al., 2008
Description
physical association
Assay
Collection
Source/Stage
brain / third instar larval stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
AGO1 

Ago1

bait
Dcr-1 

Dicer-1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was larval brains of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Xu et al., 2008)

The AGO1-Dcr-1 interaction is reduced in Fmr1 mutants.

(Xu et al., 2008)
FBrf0215456-12.coIP.WB
Reference
Miyoshi et al., 2009
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
AGO1 

AGO1

bait

FLAG tag

Dcr-1 

DCR-1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Miyoshi et al., 2009)
FBrf0215456-5.coIP.WB
Reference
Miyoshi et al., 2009
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
AGO1 

AGO1

bait
Dcr-1 

DCR-1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Glycerol sedimentation of S2 cell lysates indicates that AGO1 interacts with gw and Dcr-1 in mutually exclusive complexes.

(Miyoshi et al., 2009)

Source was cell extract of S2 cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Miyoshi et al., 2009)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (5)