FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000102205
Interaction Network
Interactions Browser links
otk network
Reported Interactions
FBrf0055961-1.BA.FM
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
otk 

Dtrk

self
otk 

Dtrk

self
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Self-association of otk protein expressed on the surface of cells is inferred from the aggregation of live cells within an hour of otk induction. This aggregation is inhibited by antibodies that bind the extracellular surface of otk.

Source was live S2 cells; protein produced from transfected constructs.

FBrf0225597-1.coIP.WB
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
otk 

Otk

bait

Myc tag

otk 

Otk

prey

GFP tag

otk 
otk 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
otk 
extracellular and transmembrane domain
sufficient binding region
aa 1-775

\'DeltaCy\' construct

otk 
intracellular and transmembrane domain
sufficient binding region
aa 475-1033

\'DeltaEx\' construct

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2R+ cell line; bait produced from transfected construct; prey produced from transfected construct.

otk forms homooligomers.

otk homooligomerization may be mediated by the transmembrane domain.

External Crossreferences and Linkouts ( 0 )
References (2)