FB2026_03 , released September 17, 2026
Physical Interaction report
Open Close
General Information
Interaction Type
physical association
Interacting Genes
dome
FlyBase ID
FBig0000103847
Interaction Network
Interactions Browser links
dome network
Reported Interactions
FBrf0160423-1.BGC
Reference
Brown et al., 2003
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
dome 

DOME

bait

βGal-Δα

dome 

DOME

prey

βGal-Δω

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryos of transgenic fly line; bait produced from transgenic construct; prey produced from transgenic construct.

(Brown et al., 2003)
FBrf0230821-1.coIP.WB
Reference
Fisher et al., 2016
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Kc167
Participants
Corresponds to
Reported as
Role
Note
dome 

Dome

bait

FLAG tag

dome 

Dome

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

dome can homodimerize.

(Fisher et al., 2016)

Source was cell extract of Kc167 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Fisher et al., 2016)
FBrf0230821-4a.BC.WB
Reference
Fisher et al., 2016
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
dome 

Dome

bait

βGal-Δα fragment

dome 

Dome

prey

βGal-Δω fragment

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Fisher et al., 2016)

dome homodimerizes as evidenced by this βGal complementation assay. dome homodimerization is inhibited by cotransfection of et.

(Fisher et al., 2016)

The proteins tested for interaction are each fused to a separate non-functional fragment of βGal. Upon interaction, the two βgal fragments come into proximity and can complement each other to give functional βgal activity.

(Fisher et al., 2016)
FBrf0239383-1.BC
Reference
Fisher et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Kc167
Participants
Corresponds to
Reported as
Role
Note
dome 

Dome

bait

βGal-Δα fragment

dome 

Dome

prey

βGal-Δω fragment

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was live Kc167 cells; proteins produced from transfected constructs.

(Fisher et al., 2018)

Knockdown of mask by RNAi decreases dome dimerization.

(Fisher et al., 2018)
FBrf0239383-2.coIP.WB
Reference
Fisher et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Kc167
Participants
Corresponds to
Reported as
Role
Note
dome 

Dome

bait

HA tag

dome 

Dome

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of Kc167 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Fisher et al., 2018)

Knockdown of mask by RNAi decreases dome dimerization.

(Fisher et al., 2018)
FBrf0254155-20.coIP.WB
Reference
Shen et al., 2022
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2R+
Participants
Corresponds to
Reported as
Role
Note
dome 

Dome

bait

FLAG tag

dome 

Dome

prey

Myc tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2R+ cell line; bait produced from transfected construct; prey produced from transfected construct.

(Shen et al., 2022)

Addition of Rel inhibits dome dimerization; addition of upd1 increases dome dimerization.

(Shen et al., 2022)
External Crossreferences and Linkouts ( 0 )
References (4)