FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Myd88, pll
FlyBase ID
FBig0000107339
Interaction Network
Interactions Browser links
Myd88 network
pll network
Reported Interactions
FBrf0139798-2.coIP.WB
Reference
Horng and Medzhitov, 2001
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-ThermoFischer
Participants
Corresponds to
Reported as
Role
Note
pll 

pelle

bait

FLAG tag

Myd88 

DMyD88

prey

V5 tag

Myd88 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Myd88 
N-terminal region
sufficient binding region
aa 1-237

coordinates relative to Myd88-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Horng and Medzhitov, 2001)
FBrf0141679-2.coIP.WB
Reference
Tauszig-Delamasure et al., 2002
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-ThermoFischer
Participants
Corresponds to
Reported as
Role
Note
pll 

Pelle

bait

FLAG tag

Myd88 

DmMyD88

prey

V5 tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Tauszig-Delamasure et al., 2002)
FBrf0152311-1.coIP.WB
Reference
Sun et al., 2002
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Myd88 

MyD88

bait
pll 

Pelle

prey

V5 tag

pll 
pll 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
pll 
death domain
sufficient binding region
aa 1-206
pll 
death domain
mutation disrupting interaction
aa 35

R35E

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Sun et al., 2002)

The amount of Myd88-associated pll was dramatically increased upon the addition of tub expression in S2 cells.

(Sun et al., 2002)
FBrf0167555-1.coIP.WB
Reference
Sun et al., 2004
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Myd88 

MyD88

bait
pll 

Pelle

prey

V5 tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Sun et al., 2004)

The Myd88-pll interaction is increased upon coexpression of the tub death domain.

(Sun et al., 2004)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (4)