FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Fmr1, chic
FlyBase ID
FBig0000109656
Interaction Network
Interactions Browser links
Fmr1 network
chic network
Reported Interactions
FBrf0187329-1.coIP.PCR
Reference
Reeve et al., 2005
Description
physical association
Assay
Collection
Source/Stage
head / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

dFMRP

bait
chic 

chickadee

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult heads; bait produced from endogenous gene; prey produced from endogenous gene.

(Reeve et al., 2005)
FBrf0235579-2.coIP.PCR
Reference
Wang et al., 2017
Description
physical association
Assay
Collection
Source/Stage
head / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

Fmr1

bait
chic 

chic

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult heads; bait produced from endogenous gene; prey produced from endogenous gene.

(Wang et al., 2017)
FBrf0248067-12.coIP.PCR
Reference
Worpenberg et al., 2021
Description
physical association
Assay
Collection
Source/Stage
organism / third instar larval stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

Fmr1

bait

GFP tag

chic 

chic

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was larvae; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Worpenberg et al., 2021)
FBrf0248067-5.coIP.PCR
Reference
Worpenberg et al., 2021
Description
physical association
Assay
Collection
Source/Stage
adult head / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

Fmr1

bait

GFP tag

chic 

chic

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult heads; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Worpenberg et al., 2021)
FBrf0248067-7.PLT.SEQ
Reference
Worpenberg et al., 2021
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2R+
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

Fmr1

bait

FLAG tag, fused to adar catalytic domain

chic 

chic

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2R+ cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Worpenberg et al., 2021)
FBrf0253571-1.coIP.PCR
Reference
Li and Gavis, 2022
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

Fmr1

bait

Flag tag

chic 

chic

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Li and Gavis, 2022)
FBrf0253571-2.coIP.PCR
Reference
Li and Gavis, 2022
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

Fmr1

bait

Flag tag

Fmr1 
chic 

chic

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Fmr1 
KH2 RNA binding domain
mutation disrupting interaction
unspecified

deletion mutation

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Li and Gavis, 2022)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (4)