FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Panx
FlyBase ID
FBig0000120944
Interaction Network
Interactions Browser links
Panx network
Reported Interactions
FBrf0248008-7.coIP.WB
Reference
Eastwood et al., 2021
Description
physical association
Assay
Collection
Source/Stage
Cell line used
OSC
Participants
Corresponds to
Reported as
Role
Note
Panx 

Panx

bait

FLAG tag

Panx 

Panx

prey

HA tag

Panx 
Panx 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Panx 
TQT motif 1
mutation decreasing interaction
aa 462-465

TQTE to GGGK, coordinates relative to Panx-PA

Panx 
TQT motifs 1 and 2
mutation disrupting interaction
aa 462-465,475-478

TQTE to GGGK,TQVR to AGGG, coordinates relative to Panx-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of OSC cell line; bait produced from transfected construct; prey produced from transfected construct.

(Eastwood et al., 2021)
FBrf0248277-19.coIP.WB
Reference
Schnabl et al., 2021
Description
physical association
Assay
Collection
Source/Stage
Cell line used
OSC
Participants
Corresponds to
Reported as
Role
Note
Panx 

Panx

bait

GFP tag

Panx 

Panx

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was extract of OSC cell line; bait produced from gene tagged at endogenous locus; prey produced from endogenous gene.

(Schnabl et al., 2021)
FBrf0248277-20.coIP.WB
Reference
Schnabl et al., 2021
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Panx 

Panx

bait

GFP tag

Panx 

Panx

prey

FLAG tag

Panx 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Panx 
C-terminal domain residues 462-464,475-476
mutation disrupting interaction
aa 462-464,475-476

TQT,TQ to A, coordinates relative to Panx-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Schnabl et al., 2021)
FBrf0248277-24.CH.MW
Reference
Schnabl et al., 2021
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Panx 

Panx

neutral component
Panx 

Panx

neutral component
Panx 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Panx 
C-terminal α helical domain
necessary binding region
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Panx dimerization was inferred from dimeric complex formation with Nxt1, nxf2 and ctp. Deletion of both ctp binding sites in Panx and the C-terminal α helices results in a monomeric complex suggesting that the α helical domain promotes Panx dimerization in the absence of ctp.

(Schnabl et al., 2021)

Interaction in vitro; proteins produced as a recombinant fusion proteins in an insect cell system.

(Schnabl et al., 2021)
External Crossreferences and Linkouts ( 0 )
References (2)