FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Sesn, Wdr59
FlyBase ID
FBig0000121860
Interaction Network
Interactions Browser links
Sesn network
Wdr59 network
Reported Interactions
FBrf0254204-1.coIP.WB
Reference
Gu et al., 2022
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Wdr59 

WDR59

bait

FLAG tag

Sesn 

Sestrin

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Addition of leucine disrupts interaction of Wdr59 and Sesn

(Gu et al., 2022)

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Gu et al., 2022)
FBrf0259115-11.coIP.WB
Reference
Liu et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Wdr59 

WDR59

bait

FLAG tag

Sesn 

Sesn

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Deprivation of leucine, but not methionine, enhances the

(Liu et al., 2024)

interaction between Wdr59 and Sesn. Addition of amino acids disrupts interaction between Wdr59 and Sesn.

(Liu et al., 2024)

Source was cell extract of HEK293T cell line; bait produced from transfected construct; prey produced from transfected construct.

(Liu et al., 2024)
FBrf0259115-7.coIP.WB
Reference
Liu et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2R+
Participants
Corresponds to
Reported as
Role
Note
Sesn 

Sesn

bait

HA tag

Wdr59 

WDR59

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2R+ cell line; bait produced from transfected construct; prey produced from transfected construct.

(Liu et al., 2024)
FBrf0259115-9.coIP.WB
Reference
Liu et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Sesn 

Sesn

bait

HA tag

Wdr59 

WDR59

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of HEK293T cell line; bait produced from transfected construct; prey produced from transfected construct.

(Liu et al., 2024)
External Crossreferences and Linkouts ( 0 )
References (2)